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- NCIT_C96746 IAO_0000115 "The succinate salt form of cevipabulin, a synthetic, water soluble tubulin-binding agent with potential antineoplastic activity. Cevipabulin binds at the vinca-binding site on tubulin, but seems to act more similar to taxane-site binding agents in that it enhances tubulin polymerization and does not induce tubulin depolymerization. This stabilizes tubulin and prevents microtubule disassembly. The disruption in microtubule dynamics may eventually inhibit cell division and reduce cellular growth." @default.
- NCIT_C96746 NCIT_A32 NCIT_C1909 @default.
- NCIT_C96746 NCIT_A6 NCIT_C77064 @default.
- NCIT_C96746 NCIT_NHC0 "C96746" @default.
- NCIT_C96746 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C96746 NCIT_P108 "Cevipabulin Succinate" @default.
- NCIT_C96746 NCIT_P207 "C3273003" @default.
- NCIT_C96746 NCIT_P210 "852954-81-5" @default.
- NCIT_C96746 NCIT_P319 "8XI0CX98LY" @default.
- NCIT_C96746 NCIT_P322 "FDA" @default.
- NCIT_C96746 NCIT_P322 "GDC" @default.
- NCIT_C96746 NCIT_P350 "C18H18ClF5N6O.C4H6O4.2H2O" @default.
- NCIT_C96746 NCIT_P375 "Cevipabulin Succinate" @default.
- NCIT_C96746 NCIT_R124 NCIT_C17828 @default.
- NCIT_C96746 NCIT_R124 NCIT_C20480 @default.
- NCIT_C96746 NCIT_R124 NCIT_C40795 @default.
- NCIT_C96746 NCIT_R124 NCIT_C40798 @default.
- NCIT_C96746 normalizedInformationContent "100" @default.
- NCIT_C96746 referenceCount "1" @default.
- NCIT_C96746 hasExactSynonym "5-chloro-6-(2,6-difluoro-4-(3-(methylamino)propoxy)phenyl)-N-((1S)-2,2,2-trifluoro-1-methylethyl)(1,2,4)triazolo(1,5-a)pyrimidin-7-amine succinate dihydrate" @default.
- NCIT_C96746 hasExactSynonym "CEVIPABULIN SUCCINATE" @default.
- NCIT_C96746 hasExactSynonym "Cevipabulin Succinate" @default.
- NCIT_C96746 hasExactSynonym "TTI-237 Succinate Dihydrate" @default.
- NCIT_C96746 inSubset NCIT_C128784 @default.
- NCIT_C96746 inSubset NCIT_C157711 @default.
- NCIT_C96746 inSubset NCIT_C157712 @default.
- NCIT_C96746 inSubset NCIT_C177537 @default.
- NCIT_C96746 inSubset NCIT_C63923 @default.
- NCIT_C96746 type Class @default.
- NCIT_C96746 isDefinedBy ncit.owl @default.
- NCIT_C96746 label "Cevipabulin Succinate" @default.
- NCIT_C96746 subClassOf NCIT_C186664 @default.
- NCIT_C96746 subClassOf NCIT_C1908 @default.
- NCIT_C96746 subClassOf NCIT_C1909 @default.
- NCIT_C96746 subClassOf NCIT_C25974 @default.
- NCIT_C96746 subClassOf NCIT_C273 @default.
- NCIT_C96746 subClassOf NCIT_C274 @default.
- NCIT_C96746 subClassOf NCIT_C96746 @default.