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- NCIT_C96747 IAO_0000115 "A quinazoline derivative with potential antineoplastic activities. Verubulin binds to and inhibits tubulin polymerization and interrupts microtubule formation, resulting in disruption of mitotic spindle assembly, cell cycle arrest in the G2/M phase, and cell death. This agent is not a substrate for several subtypes of multidrug resistance ABC transporters, and may be useful for treating multidrug resistant tumors. In addition, as a vascular disrupting agent, verubulin disrupts tumor microvasculature specifically, which may result in acute ischemia and massive tumor cell death. In addition, verubulin is able to cross the blood-brain barrier and accumulate in the brain." @default.
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- NCIT_C96747 NCIT_NHC0 "C96747" @default.
- NCIT_C96747 NCIT_P106 "Organic Chemical" @default.
- NCIT_C96747 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C96747 NCIT_P108 "Verubulin" @default.
- NCIT_C96747 NCIT_P207 "C2002404" @default.
- NCIT_C96747 NCIT_P210 "827031-83-4" @default.
- NCIT_C96747 NCIT_P319 "X97O9FTB92" @default.
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- NCIT_C96747 NCIT_P322 "GDC" @default.
- NCIT_C96747 NCIT_P350 "C17H17N3O" @default.
- NCIT_C96747 NCIT_P375 "Verubulin" @default.
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- NCIT_C96747 NCIT_R146 NCIT_C26548 @default.
- NCIT_C96747 normalizedInformationContent "100" @default.
- NCIT_C96747 referenceCount "1" @default.
- NCIT_C96747 hasExactSynonym "4-quinazolinamine, N-(4-methoxyphenyl)-N,2-dimethyl-" @default.
- NCIT_C96747 hasExactSynonym "MX-128495" @default.
- NCIT_C96747 hasExactSynonym "N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine" @default.
- NCIT_C96747 hasExactSynonym "VERUBULIN" @default.
- NCIT_C96747 hasExactSynonym "Verubulin" @default.
- NCIT_C96747 inSubset NCIT_C128784 @default.
- NCIT_C96747 inSubset NCIT_C157711 @default.
- NCIT_C96747 inSubset NCIT_C157712 @default.
- NCIT_C96747 inSubset NCIT_C177537 @default.
- NCIT_C96747 inSubset NCIT_C63923 @default.
- NCIT_C96747 type Class @default.
- NCIT_C96747 isDefinedBy ncit.owl @default.
- NCIT_C96747 label "Verubulin" @default.
- NCIT_C96747 subClassOf B020a51934e99429d220d317be5f5e017 @default.
- NCIT_C96747 subClassOf B10fbcf9905a35930c9b1154d37bd9212 @default.
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- NCIT_C96747 subClassOf NCIT_C186664 @default.
- NCIT_C96747 subClassOf NCIT_C1908 @default.
- NCIT_C96747 subClassOf NCIT_C1909 @default.
- NCIT_C96747 subClassOf NCIT_C25974 @default.
- NCIT_C96747 subClassOf NCIT_C273 @default.
- NCIT_C96747 subClassOf NCIT_C274 @default.
- NCIT_C96747 subClassOf NCIT_C96747 @default.