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- NCIT_C96795 IAO_0000115 "An orally available inhibitor of the nuclear enzymes poly(ADP-ribose) polymerase (PARP) 1 and 2, with potential antineoplastic activity. Upon administration, ABT-767 selectively binds to PARP 1 and 2, thereby preventing repair of damaged DNA via the base excision repair (BER) pathway. This agent enhances the accumulation of DNA strand breaks and promotes genomic instability eventually leading to apoptosis. ABT-767 may enhance the cytotoxicity of DNA-damaging agents and reverse tumor cell chemo- and radioresistance. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and can be activated by single strand DNA (ssDNA) breaks." @default.
- NCIT_C96795 NCIT_A32 NCIT_C1909 @default.
- NCIT_C96795 NCIT_NHC0 "C96795" @default.
- NCIT_C96795 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C96795 NCIT_P108 "PARP-1/2 Inhibitor ABT-767" @default.
- NCIT_C96795 NCIT_P208 "CL429404" @default.
- NCIT_C96795 NCIT_P322 "GDC" @default.
- NCIT_C96795 NCIT_P329 "699738" @default.
- NCIT_C96795 NCIT_P330 "699738" @default.
- NCIT_C96795 NCIT_P375 "PARP-1/2 Inhibitor ABT-767" @default.
- NCIT_C96795 NCIT_P399 "699738" @default.
- NCIT_C96795 NCIT_R146 NCIT_C104101 @default.
- NCIT_C96795 NCIT_R146 NCIT_C16554 @default.
- NCIT_C96795 NCIT_R146 NCIT_C17021 @default.
- NCIT_C96795 NCIT_R146 NCIT_C17210 @default.
- NCIT_C96795 NCIT_R146 NCIT_C17434 @default.
- NCIT_C96795 NCIT_R146 NCIT_C20027 @default.
- NCIT_C96795 NCIT_R146 NCIT_C21170 @default.
- NCIT_C96795 NCIT_R146 NCIT_C26548 @default.
- NCIT_C96795 NCIT_R146 NCIT_C48215 @default.
- NCIT_C96795 normalizedInformationContent "100" @default.
- NCIT_C96795 referenceCount "1" @default.
- NCIT_C96795 hasExactSynonym "ABT-767" @default.
- NCIT_C96795 hasExactSynonym "PARP-1/2 Inhibitor ABT-767" @default.
- NCIT_C96795 inSubset NCIT_C128784 @default.
- NCIT_C96795 inSubset NCIT_C157711 @default.
- NCIT_C96795 inSubset NCIT_C157712 @default.
- NCIT_C96795 inSubset NCIT_C176424 @default.
- NCIT_C96795 inSubset NCIT_C177537 @default.
- NCIT_C96795 type Class @default.
- NCIT_C96795 isDefinedBy ncit.owl @default.
- NCIT_C96795 label "PARP-1/2 Inhibitor ABT-767" @default.
- NCIT_C96795 subClassOf NCIT_C163758 @default.
- NCIT_C96795 subClassOf NCIT_C1908 @default.
- NCIT_C96795 subClassOf NCIT_C1909 @default.
- NCIT_C96795 subClassOf NCIT_C274 @default.
- NCIT_C96795 subClassOf NCIT_C471 @default.
- NCIT_C96795 subClassOf NCIT_C62554 @default.
- NCIT_C96795 subClassOf NCIT_C96795 @default.