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- NCIT_C96797 IAO_0000115 "An orally bioavailable benzamide and inhibitor of human class I histone deacetylases (HDACs) isoenzymes 1, 2 and 3, with potential antineoplastic activity. Domatinostat selectively binds to and inhibits class I HDACs leading to an accumulation of highly acetylated histones. This may result in an induction of chromatin remodeling, the selective transcription of tumor suppressor genes, and the tumor suppressor protein-mediated inhibition of tumor cell division and eventually the induction of tumor cell apoptosis. This may inhibit tumor cell proliferation in susceptible tumor cells. HDACs, upregulated in many tumor types, are a class of enzymes that deacetylate chromatin histone proteins." @default.
- NCIT_C96797 NCIT_A32 NCIT_C1909 @default.
- NCIT_C96797 NCIT_A7 NCIT_C16682 @default.
- NCIT_C96797 NCIT_NHC0 "C96797" @default.
- NCIT_C96797 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C96797 NCIT_P107 "Domatinostat" @default.
- NCIT_C96797 NCIT_P108 "Domatinostat" @default.
- NCIT_C96797 NCIT_P208 "CL429405" @default.
- NCIT_C96797 NCIT_P210 "910462-43-0" @default.
- NCIT_C96797 NCIT_P319 "264ARM7UXX" @default.
- NCIT_C96797 NCIT_P322 "CTRP" @default.
- NCIT_C96797 NCIT_P322 "FDA" @default.
- NCIT_C96797 NCIT_P322 "GDC" @default.
- NCIT_C96797 NCIT_P329 "700110" @default.
- NCIT_C96797 NCIT_P330 "700110" @default.
- NCIT_C96797 NCIT_P375 "Domatinostat" @default.
- NCIT_C96797 NCIT_P399 "700110" @default.
- NCIT_C96797 normalizedInformationContent "100" @default.
- NCIT_C96797 referenceCount "1" @default.
- NCIT_C96797 hasExactSynonym "2-Propenamide, N-(2-aminophenyl)-3-(1-((4-(1-methyl-1H-pyrazol-4-yl)phenyl)sulfonyl)-1H-pyrrol-3-yl)-, (2E)-" @default.
- NCIT_C96797 hasExactSynonym "4SC-202" @default.
- NCIT_C96797 hasExactSynonym "DOMATINOSTAT" @default.
- NCIT_C96797 hasExactSynonym "Domatinostat" @default.
- NCIT_C96797 inSubset NCIT_C116977 @default.
- NCIT_C96797 inSubset NCIT_C116978 @default.
- NCIT_C96797 inSubset NCIT_C128784 @default.
- NCIT_C96797 inSubset NCIT_C157711 @default.
- NCIT_C96797 inSubset NCIT_C157712 @default.
- NCIT_C96797 inSubset NCIT_C176424 @default.
- NCIT_C96797 inSubset NCIT_C177537 @default.
- NCIT_C96797 inSubset NCIT_C63923 @default.
- NCIT_C96797 type Class @default.
- NCIT_C96797 isDefinedBy ncit.owl @default.
- NCIT_C96797 label "Domatinostat" @default.
- NCIT_C96797 subClassOf NCIT_C129824 @default.
- NCIT_C96797 subClassOf NCIT_C129825 @default.
- NCIT_C96797 subClassOf NCIT_C163758 @default.
- NCIT_C96797 subClassOf NCIT_C1908 @default.
- NCIT_C96797 subClassOf NCIT_C1909 @default.
- NCIT_C96797 subClassOf NCIT_C1946 @default.
- NCIT_C96797 subClassOf NCIT_C2189 @default.
- NCIT_C96797 subClassOf NCIT_C274 @default.
- NCIT_C96797 subClassOf NCIT_C471 @default.
- NCIT_C96797 subClassOf NCIT_C96797 @default.