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- NCIT_C97038 IAO_0000115 "Autologous chimeric immune receptor (CIR) T cells transfected with anti-mesothelin chimeric T cell receptor mRNA, with potential antineoplastic activity. The anti-mesothelin mRNA encodes a single chain antibody variable fragment (ScFv), the intracellular CD 3 zeta T cell receptor domain and the 4-1BB (cd137) costimulatory domain. Upon intravenous administration, the anti-mesothelin CIR mRNA-electroporated autologous T cells may attach to cancer cells expressing mesothelin. This may stimulate the secretion of multiple cytokines and may result in cell lysis of mesothelin-expressing cancer cells. Mesothelin is a cell surface glycoprotein involved in cell adhesion and is overexpressed in many epithelial-derived cancers." @default.
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- NCIT_C97038 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C97038 NCIT_P107 "Anti-mesothelin CIR mRNA-electroporated Autologous T Cells" @default.
- NCIT_C97038 NCIT_P108 "Anti-mesothelin CIR mRNA-electroporated Autologous T Cells" @default.
- NCIT_C97038 NCIT_P208 "CL429645" @default.
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- NCIT_C97038 hasExactSynonym "Anti-mesothelin CIR mRNA-electroporated Autologous T Cells" @default.
- NCIT_C97038 hasExactSynonym "Autologous Redirected RNA Meso-CIR T cells" @default.
- NCIT_C97038 inSubset NCIT_C116977 @default.
- NCIT_C97038 inSubset NCIT_C116978 @default.
- NCIT_C97038 inSubset NCIT_C128784 @default.
- NCIT_C97038 inSubset NCIT_C176424 @default.
- NCIT_C97038 type Class @default.
- NCIT_C97038 isDefinedBy ncit.owl @default.
- NCIT_C97038 label "Anti-mesothelin CIR mRNA-electroporated Autologous T Cells" @default.
- NCIT_C97038 subClassOf NCIT_C129820 @default.
- NCIT_C97038 subClassOf NCIT_C129821 @default.
- NCIT_C97038 subClassOf NCIT_C129826 @default.
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- NCIT_C97038 subClassOf NCIT_C97038 @default.