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- NCIT_C97040 IAO_0000115 "A dual inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR), with potential antineoplastic activity. CC-115 binds to and inhibits the activity of DNA-PK and both raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2), which may lead to a reduction in cellular proliferation of cancer cells expressing DNA-PK and TOR. DNA-PK, a serine/threonine kinase and a member of the PI3K-related kinase subfamily of protein kinases, is activated upon DNA damage and plays a key role in repairing double-stranded DNA breaks via the DNA nonhomologous end joining (NHEJ) pathway; mTOR, a serine/threonine kinase that is upregulated in a variety of tumors, plays an important role downstream in the PI3K/Akt/mTOR signaling pathway." @default.
- NCIT_C97040 NCIT_A32 NCIT_C1909 @default.
- NCIT_C97040 NCIT_A7 NCIT_C21483 @default.
- NCIT_C97040 NCIT_A7 NCIT_C96314 @default.
- NCIT_C97040 NCIT_A7 NCIT_C96315 @default.
- NCIT_C97040 NCIT_NHC0 "C97040" @default.
- NCIT_C97040 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C97040 NCIT_P107 "DNA-PK/TOR Kinase Inhibitor CC-115" @default.
- NCIT_C97040 NCIT_P108 "DNA-PK/TOR Kinase Inhibitor CC-115" @default.
- NCIT_C97040 NCIT_P207 "C3273208" @default.
- NCIT_C97040 NCIT_P210 "1228013-15-7" @default.
- NCIT_C97040 NCIT_P319 "FII75TFH5L" @default.
- NCIT_C97040 NCIT_P322 "CTRP" @default.
- NCIT_C97040 NCIT_P322 "FDA" @default.
- NCIT_C97040 NCIT_P322 "GDC" @default.
- NCIT_C97040 NCIT_P329 "700650" @default.
- NCIT_C97040 NCIT_P330 "700650" @default.
- NCIT_C97040 NCIT_P375 "DNA-PK/TOR Kinase Inhibitor CC-115" @default.
- NCIT_C97040 NCIT_P399 "700650" @default.
- NCIT_C97040 normalizedInformationContent "100" @default.
- NCIT_C97040 referenceCount "1" @default.
- NCIT_C97040 hasExactSynonym "CC-115" @default.
- NCIT_C97040 hasExactSynonym "DNA-PK/TOR Kinase Inhibitor CC-115" @default.
- NCIT_C97040 inSubset NCIT_C116977 @default.
- NCIT_C97040 inSubset NCIT_C116978 @default.
- NCIT_C97040 inSubset NCIT_C128784 @default.
- NCIT_C97040 inSubset NCIT_C157711 @default.
- NCIT_C97040 inSubset NCIT_C157712 @default.
- NCIT_C97040 inSubset NCIT_C176424 @default.
- NCIT_C97040 inSubset NCIT_C177537 @default.
- NCIT_C97040 inSubset NCIT_C63923 @default.
- NCIT_C97040 type Class @default.
- NCIT_C97040 isDefinedBy ncit.owl @default.
- NCIT_C97040 label "DNA-PK/TOR Kinase Inhibitor CC-115" @default.
- NCIT_C97040 subClassOf NCIT_C129824 @default.
- NCIT_C97040 subClassOf NCIT_C129825 @default.
- NCIT_C97040 subClassOf NCIT_C1404 @default.
- NCIT_C97040 subClassOf NCIT_C163758 @default.
- NCIT_C97040 subClassOf NCIT_C1908 @default.
- NCIT_C97040 subClassOf NCIT_C1909 @default.
- NCIT_C97040 subClassOf NCIT_C192218 @default.
- NCIT_C97040 subClassOf NCIT_C2189 @default.
- NCIT_C97040 subClassOf NCIT_C2201 @default.
- NCIT_C97040 subClassOf NCIT_C274 @default.
- NCIT_C97040 subClassOf NCIT_C471 @default.
- NCIT_C97040 subClassOf NCIT_C61074 @default.
- NCIT_C97040 subClassOf NCIT_C97040 @default.