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- NCIT_C971 IAO_0000115 "An iodinated doxorubicin analogue with antiamyloid activity. 4'-Iodo-4'-deoxydoxorubicin (IDOX) binds with high affinity to five types of natural amyloid fibrils including immunoglobulin light chains, amyloid A, transthyretin (methionine-30 variant), beta-protein (Alzheimer), and beta2-microglobulin. This agent may inhibit fibril growth, increasing the solubility of amyloid tissue deposits and facilitating their clearance. IDOX has also been shown to insulin amyloid fibrillogenesis in vitro." @default.
- NCIT_C971 NCIT_A32 NCIT_C1909 @default.
- NCIT_C971 NCIT_NHC0 "C971" @default.
- NCIT_C971 NCIT_P106 "Antibiotic" @default.
- NCIT_C971 NCIT_P106 "Organic Chemical" @default.
- NCIT_C971 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C971 NCIT_P107 "4'-Iodo-4'-Deoxydoxorubicin" @default.
- NCIT_C971 NCIT_P108 "4'-Iodo-4'-Deoxydoxorubicin" @default.
- NCIT_C971 NCIT_P175 "378901" @default.
- NCIT_C971 NCIT_P207 "C0047758" @default.
- NCIT_C971 NCIT_P210 "83997-75-5" @default.
- NCIT_C971 NCIT_P319 "65JH75I9JX" @default.
- NCIT_C971 NCIT_P322 "CTRP" @default.
- NCIT_C971 NCIT_P322 "FDA" @default.
- NCIT_C971 NCIT_P322 "GDC" @default.
- NCIT_C971 NCIT_P325 "A substance that is being studied as a treatment for cancer, and for primary systemic amyloidosis (a disease in which proteins are deposited in specific organs). It belongs to the family of drugs called anthracycline analogues." @default.
- NCIT_C971 NCIT_P329 "41162" @default.
- NCIT_C971 NCIT_P330 "41162" @default.
- NCIT_C971 NCIT_P366 "_4_Iodo-4_Deoxydoxorubicin" @default.
- NCIT_C971 NCIT_P368 "CHEBI:47897" @default.
- NCIT_C971 NCIT_P375 "4'-Iodo-4'-Deoxydoxorubicin" @default.
- NCIT_C971 NCIT_P399 "41162" @default.
- NCIT_C971 NCIT_R124 NCIT_C17710 @default.
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- NCIT_C971 NCIT_R124 NCIT_C19986 @default.
- NCIT_C971 NCIT_R124 NCIT_C40492 @default.
- NCIT_C971 NCIT_R124 NCIT_C40523 @default.
- NCIT_C971 NCIT_R124 NCIT_C41565 @default.
- NCIT_C971 NCIT_R125 NCIT_C16507 @default.
- NCIT_C971 NCIT_R125 NCIT_C16514 @default.
- NCIT_C971 NCIT_R125 NCIT_C16956 @default.
- NCIT_C971 NCIT_R125 NCIT_C17710 @default.
- NCIT_C971 NCIT_R125 NCIT_C17828 @default.
- NCIT_C971 NCIT_R125 NCIT_C18264 @default.
- NCIT_C971 NCIT_R125 NCIT_C19154 @default.
- NCIT_C971 NCIT_R125 NCIT_C21080 @default.
- NCIT_C971 NCIT_R125 NCIT_C25830 @default.
- NCIT_C971 NCIT_R125 NCIT_C28498 @default.
- NCIT_C971 NCIT_R125 NCIT_C40828 @default.
- NCIT_C971 NCIT_R125 NCIT_C41543 @default.
- NCIT_C971 NCIT_R125 NCIT_C44955 @default.
- NCIT_C971 NCIT_R125 NCIT_C45553 @default.
- NCIT_C971 normalizedInformationContent "100" @default.
- NCIT_C971 referenceCount "1" @default.
- NCIT_C971 hasExactSynonym "4'-Deoxy-4'-Iododoxorubicin" @default.
- NCIT_C971 hasExactSynonym "4'-Iodo-4'-Deoxydoxorubicin" @default.
- NCIT_C971 hasExactSynonym "IDOX" @default.
- NCIT_C971 hasExactSynonym "IODODOXORUBICIN" @default.
- NCIT_C971 hasExactSynonym "Iodo-Doxorubicin" @default.
- NCIT_C971 hasExactSynonym "Iododoxorubicin" @default.
- NCIT_C971 hasExactSynonym "iododoxorubicin" @default.
- NCIT_C971 inSubset NCIT_C116977 @default.
- NCIT_C971 inSubset NCIT_C116978 @default.
- NCIT_C971 inSubset NCIT_C128784 @default.
- NCIT_C971 inSubset NCIT_C157711 @default.
- NCIT_C971 inSubset NCIT_C157712 @default.
- NCIT_C971 inSubset NCIT_C176424 @default.
- NCIT_C971 inSubset NCIT_C177537 @default.
- NCIT_C971 inSubset NCIT_C63923 @default.
- NCIT_C971 type Class @default.
- NCIT_C971 isDefinedBy ncit.owl @default.
- NCIT_C971 label "4'-Iodo-4'-Deoxydoxorubicin" @default.
- NCIT_C971 subClassOf NCIT_C129824 @default.
- NCIT_C971 subClassOf NCIT_C129825 @default.
- NCIT_C971 subClassOf NCIT_C1594 @default.
- NCIT_C971 subClassOf NCIT_C1748 @default.
- NCIT_C971 subClassOf NCIT_C186664 @default.
- NCIT_C971 subClassOf NCIT_C1908 @default.
- NCIT_C971 subClassOf NCIT_C1909 @default.
- NCIT_C971 subClassOf NCIT_C1968 @default.
- NCIT_C971 subClassOf NCIT_C2115 @default.
- NCIT_C971 subClassOf NCIT_C2161 @default.
- NCIT_C971 subClassOf NCIT_C2189 @default.
- NCIT_C971 subClassOf NCIT_C259 @default.
- NCIT_C971 subClassOf NCIT_C274 @default.
- NCIT_C971 subClassOf NCIT_C2842 @default.
- NCIT_C971 subClassOf NCIT_C471 @default.
- NCIT_C971 subClassOf NCIT_C971 @default.
- NCIT_C971 equivalentClass B22e05357506ca5bac027cb6839b48534 @default.
- NCIT_C971 equivalentClass Bc44e39d4e1aa945e8132c9da0217605c @default.