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- NCIT_C97263 IAO_0000115 "An orally bioavailable benzamide-type inhibitor of histone deacetylase (HDAC) isoenzymes 1, 2, 3 and 10, with potential antineoplastic activity. Upon administration, tucidinostat binds to and inhibits HDACs, leading to an increase of acetylation levels of histone proteins. This agent also inhibits the expression of kinases in the PI3K/Akt and MAPK/Ras signaling pathways and may result in cell cycle arrest and the induction of tumor cell apoptosis. This may inhibit tumor cell proliferation in susceptible tumor cells. HDACs, a class of enzymes that deacetylate chromatin histone proteins, are upregulated in many tumor types and play key roles in gene expression. Compared to some other benzamide-type HDAC inhibitors, chidamide is more stable, more resistant to degradation and has a longer half-life." @default.
- NCIT_C97263 NCIT_A32 NCIT_C1909 @default.
- NCIT_C97263 NCIT_A7 NCIT_C104508 @default.
- NCIT_C97263 NCIT_A7 NCIT_C18294 @default.
- NCIT_C97263 NCIT_A7 NCIT_C19671 @default.
- NCIT_C97263 NCIT_A7 NCIT_C19672 @default.
- NCIT_C97263 NCIT_NHC0 "C97263" @default.
- NCIT_C97263 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C97263 NCIT_P107 "Tucidinostat" @default.
- NCIT_C97263 NCIT_P108 "Tucidinostat" @default.
- NCIT_C97263 NCIT_P207 "C2932486" @default.
- NCIT_C97263 NCIT_P210 "1616493-44-7" @default.
- NCIT_C97263 NCIT_P319 "87CIC980Y0" @default.
- NCIT_C97263 NCIT_P322 "CTRP" @default.
- NCIT_C97263 NCIT_P322 "FDA" @default.
- NCIT_C97263 NCIT_P322 "GDC" @default.
- NCIT_C97263 NCIT_P329 "702501" @default.
- NCIT_C97263 NCIT_P330 "702501" @default.
- NCIT_C97263 NCIT_P375 "Tucidinostat" @default.
- NCIT_C97263 NCIT_P399 "702501" @default.
- NCIT_C97263 normalizedInformationContent "100" @default.
- NCIT_C97263 referenceCount "1" @default.
- NCIT_C97263 hasExactSynonym "CS-055" @default.
- NCIT_C97263 hasExactSynonym "CS055" @default.
- NCIT_C97263 hasExactSynonym "Chidamide" @default.
- NCIT_C97263 hasExactSynonym "Epidaza" @default.
- NCIT_C97263 hasExactSynonym "HBI-8000" @default.
- NCIT_C97263 hasExactSynonym "N-(2-amino-5-fluorine benzyl)-4-[N-(pyridine-3-acrylyl) ammonia methyl] Benzamide" @default.
- NCIT_C97263 hasExactSynonym "N-(2-amino-5-fluorophenyl)-4-[[[1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]-benzamide" @default.
- NCIT_C97263 hasExactSynonym "TUCIDINOSTAT" @default.
- NCIT_C97263 hasExactSynonym "Tucidinostat" @default.
- NCIT_C97263 inSubset NCIT_C116977 @default.
- NCIT_C97263 inSubset NCIT_C116978 @default.
- NCIT_C97263 inSubset NCIT_C128784 @default.
- NCIT_C97263 inSubset NCIT_C157711 @default.
- NCIT_C97263 inSubset NCIT_C157712 @default.
- NCIT_C97263 inSubset NCIT_C176424 @default.
- NCIT_C97263 inSubset NCIT_C177537 @default.
- NCIT_C97263 inSubset NCIT_C63923 @default.
- NCIT_C97263 type Class @default.
- NCIT_C97263 isDefinedBy ncit.owl @default.
- NCIT_C97263 label "Tucidinostat" @default.
- NCIT_C97263 subClassOf NCIT_C163758 @default.
- NCIT_C97263 subClassOf NCIT_C1908 @default.
- NCIT_C97263 subClassOf NCIT_C1909 @default.
- NCIT_C97263 subClassOf NCIT_C1946 @default.
- NCIT_C97263 subClassOf NCIT_C274 @default.
- NCIT_C97263 subClassOf NCIT_C471 @default.
- NCIT_C97263 subClassOf NCIT_C97263 @default.