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- NCIT_C97272 IAO_0000115 "The dihydrochloride salt form of quizartinib, an orally available small molecule with potential antineoplastic activity. Quizartinib selectively inhibits class III receptor tyrosine kinases, including FMS-related tyrosine kinase 3 (FLT3/STK1), colony-stimulating factor 1 receptor (CSF1R/FMS), stem cell factor receptor (SCFR/KIT), and platelet derived growth factor receptors (PDGFRs), resulting in inhibition of ligand-independent leukemic cell proliferation and apoptosis. Mutations in FLT3, resulting in constitutive activation, are the most frequent genetic alterations in acute myeloid leukemia (AML) and occur in approximately one-third of AML cases." @default.
- NCIT_C97272 NCIT_A6 NCIT_C68936 @default.
- NCIT_C97272 NCIT_NHC0 "C97272" @default.
- NCIT_C97272 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C97272 NCIT_P107 "Quizartinib Dihydrochloride" @default.
- NCIT_C97272 NCIT_P108 "Quizartinib Dihydrochloride" @default.
- NCIT_C97272 NCIT_P207 "C3273320" @default.
- NCIT_C97272 NCIT_P210 "1132827-21-4" @default.
- NCIT_C97272 NCIT_P319 "WK7Q6ZIZ10" @default.
- NCIT_C97272 NCIT_P322 "CTRP" @default.
- NCIT_C97272 NCIT_P322 "FDA" @default.
- NCIT_C97272 NCIT_P329 "547019" @default.
- NCIT_C97272 NCIT_P330 "547019" @default.
- NCIT_C97272 NCIT_P350 "C29H32N6O4S.2ClH" @default.
- NCIT_C97272 NCIT_P399 "547019" @default.
- NCIT_C97272 normalizedInformationContent "100" @default.
- NCIT_C97272 referenceCount "1" @default.
- NCIT_C97272 hasExactSynonym "AC010220 2HCl" @default.
- NCIT_C97272 hasExactSynonym "AC220 2HCL" @default.
- NCIT_C97272 hasExactSynonym "N-(5-Tert-butyl-isoxazol-3-yl)-N'-(4-(7-(2-morpholin-4-ylethoxy)imidazo(2,1-b)(1,3)benzothiazol-2-yl)phenyl)urea Dihydrochloride" @default.
- NCIT_C97272 hasExactSynonym "QUIZARTINIB DIHYDROCHLORIDE" @default.
- NCIT_C97272 hasExactSynonym "Quizartinib Dihydrochloride" @default.
- NCIT_C97272 hasExactSynonym "Urea, N-(5-(1,1-dimethylethyl)-3-isoxazolyl)-N'-(4-(7-(2-(4-morpholinyl) ethoxy)imidazo(2,1-b)benzothiazol-2-yl)phenyl)-, Hydrochloride (1:2)" @default.
- NCIT_C97272 inSubset NCIT_C116977 @default.
- NCIT_C97272 inSubset NCIT_C116978 @default.
- NCIT_C97272 inSubset NCIT_C176424 @default.
- NCIT_C97272 inSubset NCIT_C63923 @default.
- NCIT_C97272 type Class @default.
- NCIT_C97272 isDefinedBy ncit.owl @default.
- NCIT_C97272 label "Quizartinib Dihydrochloride" @default.
- NCIT_C97272 subClassOf NCIT_C124800 @default.
- NCIT_C97272 subClassOf NCIT_C129820 @default.
- NCIT_C97272 subClassOf NCIT_C129824 @default.
- NCIT_C97272 subClassOf NCIT_C129825 @default.
- NCIT_C97272 subClassOf NCIT_C1404 @default.
- NCIT_C97272 subClassOf NCIT_C159198 @default.
- NCIT_C97272 subClassOf NCIT_C159199 @default.
- NCIT_C97272 subClassOf NCIT_C163758 @default.
- NCIT_C97272 subClassOf NCIT_C163790 @default.
- NCIT_C97272 subClassOf NCIT_C163999 @default.
- NCIT_C97272 subClassOf NCIT_C164037 @default.
- NCIT_C97272 subClassOf NCIT_C1908 @default.
- NCIT_C97272 subClassOf NCIT_C1909 @default.
- NCIT_C97272 subClassOf NCIT_C1967 @default.
- NCIT_C97272 subClassOf NCIT_C198643 @default.
- NCIT_C97272 subClassOf NCIT_C198646 @default.
- NCIT_C97272 subClassOf NCIT_C2189 @default.
- NCIT_C97272 subClassOf NCIT_C274 @default.
- NCIT_C97272 subClassOf NCIT_C308 @default.
- NCIT_C97272 subClassOf NCIT_C471 @default.
- NCIT_C97272 subClassOf NCIT_C97272 @default.