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- NCIT_C97273 IAO_0000115 "The dimaleate salt form of afatinib, an orally bioavailable anilino-quinazoline derivative and inhibitor of the receptor tyrosine kinase (RTK) epidermal growth factor receptor (ErbB; EGFR) family, with antineoplastic activity. Upon administration, afatinib selectively and irreversibly binds to and inhibits the epidermal growth factor receptors 1 (ErbB1; EGFR), 2 (ErbB2; HER2), and 4 (ErbB4; HER4), and certain EGFR mutants, including those caused by EGFR exon 19 deletion mutations or exon 21 (L858R) mutations. This may result in the inhibition of tumor growth and angiogenesis in tumor cells overexpressing these RTKs. Additionally, afatinib inhibits the EGFR T790M gatekeeper mutation which is resistant to treatment with first-generation EGFR inhibitors. EGFR, HER2 and HER4 are RTKs that belong to the EGFR superfamily; they play major roles in both tumor cell proliferation and tumor vascularization and are overexpressed in many cancer cell types." @default.
- NCIT_C97273 NCIT_A32 NCIT_C1909 @default.
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- NCIT_C97273 NCIT_A7 NCIT_C17319 @default.
- NCIT_C97273 NCIT_NHC0 "C97273" @default.
- NCIT_C97273 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C97273 NCIT_P107 "Afatinib Dimaleate" @default.
- NCIT_C97273 NCIT_P108 "Afatinib Dimaleate" @default.
- NCIT_C97273 NCIT_P207 "C1879772" @default.
- NCIT_C97273 NCIT_P210 "850140-73-7" @default.
- NCIT_C97273 NCIT_P302 "metastatic non-small cell lung cancer (NSCLC) whose tumors have non-resistant epidermal growth factor receptor (EGFR) mutations" @default.
- NCIT_C97273 NCIT_P319 "V1T5K7RZ0B" @default.
- NCIT_C97273 NCIT_P322 "CTRP" @default.
- NCIT_C97273 NCIT_P322 "FDA" @default.
- NCIT_C97273 NCIT_P322 "GDC" @default.
- NCIT_C97273 NCIT_P329 "537572" @default.
- NCIT_C97273 NCIT_P330 "537572" @default.
- NCIT_C97273 NCIT_P375 "Afatinib Dimaleate" @default.
- NCIT_C97273 NCIT_P399 "537572" @default.
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- NCIT_C97273 NCIT_R146 NCIT_C26548 @default.
- NCIT_C97273 NCIT_R146 NCIT_C45842 @default.
- NCIT_C97273 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C97273 referenceCount "2" @default.
- NCIT_C97273 hasExactSynonym "(2E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((3S)-tetrahydrofuran-3-yl)oxy)quinazolin- 6-yl)-4-(dimethylamino)but-2-enamide bis(hydrogen (2Z)-but-2-enedioate)" @default.
- NCIT_C97273 hasExactSynonym "2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-,(2E)-, (2Z)-2-Butenedioate (1:2)" @default.
- NCIT_C97273 hasExactSynonym "AFATINIB DIMALEATE" @default.
- NCIT_C97273 hasExactSynonym "Afatinib Dimaleate" @default.
- NCIT_C97273 hasExactSynonym "BIBW 2992MA2" @default.
- NCIT_C97273 hasExactSynonym "BIBW2992 MA2" @default.
- NCIT_C97273 hasExactSynonym "Gilotrif" @default.
- NCIT_C97273 inSubset NCIT_C116977 @default.
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- NCIT_C97273 inSubset NCIT_C63923 @default.
- NCIT_C97273 type Class @default.
- NCIT_C97273 isDefinedBy ncit.owl @default.
- NCIT_C97273 label "Afatinib Dimaleate" @default.
- NCIT_C97273 subClassOf B08147f37ee87d9945ec921fff173a7ed @default.
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