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- NCIT_C97332 IAO_0000115 "A third-generation epothilone B analogue with potential anti-mitotic and antineoplastic activites. Iso-fludelone binds to tubulin and induces microtubule polymerization and stabilizes microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. Compared to other generations of epothilones, iso-fludelone exhibits increased stability, water solubility, potency, duration of action, tumor penetration as well as reduced toxicity. In addition, this agent is a not a substrate of the P-glycoprotein (P-gp), a multidrug resistance pump often overexpressed in cancer cells." @default.
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- NCIT_C97332 NCIT_P106 "Organic Chemical" @default.
- NCIT_C97332 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C97332 NCIT_P107 "Iso-fludelone" @default.
- NCIT_C97332 NCIT_P108 "Iso-fludelone" @default.
- NCIT_C97332 NCIT_P208 "CL429824" @default.
- NCIT_C97332 NCIT_P210 "693272-98-9" @default.
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- NCIT_C97332 NCIT_P329 "703135" @default.
- NCIT_C97332 NCIT_P330 "703135" @default.
- NCIT_C97332 NCIT_P375 "Iso-fludelone" @default.
- NCIT_C97332 NCIT_P399 "703135" @default.
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- NCIT_C97332 normalizedInformationContent "100" @default.
- NCIT_C97332 referenceCount "1" @default.
- NCIT_C97332 hasExactSynonym "17-Iso-oxazole-26-F3-9,10-dehydro-12,13-desoxy-epothilone B" @default.
- NCIT_C97332 hasExactSynonym "17-Iso-oxazole-fludelone" @default.
- NCIT_C97332 hasExactSynonym "Iso-fludelone" @default.
- NCIT_C97332 hasExactSynonym "KOS-1803" @default.
- NCIT_C97332 hasExactSynonym "KOSN-1724" @default.
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- NCIT_C97332 type Class @default.
- NCIT_C97332 isDefinedBy ncit.owl @default.
- NCIT_C97332 label "Iso-fludelone" @default.
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