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- NCIT_C97334 IAO_0000115 "A radiotracer containing a pegylated dimeric Arg-Gly-Asp (RGD) peptide (NH2-mini-PEG-E[c(RGDyK)]2 or PRGD2) radiolabeled with fluorine 18F-fluorobenzoate (18F-FB), with potential alphaVbeta3 integrin imaging activity upon positron emission topography (PET). Upon administration, the RGD moiety of 18F-labeled Mini-PEG Spacered RGD Dimer (18F-FPRGD2) binds to alphaVbeta3 integrin. Upon PET, alphaVbeta3-expressing tumor cells can be visualized and the degree of tumor angiogenesis can be determined. This agent exhibits increased integrin receptor binding affinity, tumor cell uptake and increased radiolabeling yield as compared to the non-pegylated form (18F-FRGD2). Integrins, transmembrane glycoproteins, may be upregulated on proliferating tumor vessel endothelial cells and various cancer cells; their overexpression has been associated with neovascularization, differentiation, proliferation of tumor cells, metastasis and an overall poor prognosis." @default.
- NCIT_C97334 NCIT_A7 NCIT_C38953 @default.
- NCIT_C97334 NCIT_NHC0 "C97334" @default.
- NCIT_C97334 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C97334 NCIT_P107 "18F-labeled Mini-PEG Spacered RGD Dimer" @default.
- NCIT_C97334 NCIT_P108 "18F-labeled Mini-PEG Spacered RGD Dimer" @default.
- NCIT_C97334 NCIT_P208 "CL429825" @default.
- NCIT_C97334 NCIT_P322 "CTRP" @default.
- NCIT_C97334 NCIT_P329 "703211" @default.
- NCIT_C97334 NCIT_P330 "703211" @default.
- NCIT_C97334 NCIT_P399 "703211" @default.
- NCIT_C97334 normalizedInformationContent "100" @default.
- NCIT_C97334 referenceCount "1" @default.
- NCIT_C97334 hasExactSynonym "(18)F-FB-mini-PEG-E[c(RGDyK)](2)" @default.
- NCIT_C97334 hasExactSynonym "18F-FPRGD2" @default.
- NCIT_C97334 hasExactSynonym "18F-labeled Mini-PEG Spacered RGD Dimer" @default.
- NCIT_C97334 hasExactSynonym "[18F] FPRGD2" @default.
- NCIT_C97334 inSubset NCIT_C116977 @default.
- NCIT_C97334 inSubset NCIT_C116978 @default.
- NCIT_C97334 inSubset NCIT_C176424 @default.
- NCIT_C97334 type Class @default.
- NCIT_C97334 isDefinedBy ncit.owl @default.
- NCIT_C97334 label "18F-labeled Mini-PEG Spacered RGD Dimer" @default.
- NCIT_C97334 subClassOf NCIT_C1446 @default.
- NCIT_C97334 subClassOf NCIT_C1908 @default.
- NCIT_C97334 subClassOf NCIT_C1909 @default.
- NCIT_C97334 subClassOf NCIT_C2124 @default.
- NCIT_C97334 subClassOf NCIT_C97334 @default.