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- NCIT_C97466 IAO_0000115 "A recombinant modified mammalian urate oxidase (uricase) conjugated to monomethoxypolyethylene glycol (mPEG), that can be used to lower serum uric acid. Upon intravenous infusion, pegloticase catalyzes the oxidation of uric acid to allantoin, thereby lowering serum uric acid. Allantoin is an inert and water-soluble purine metabolite; it is readily eliminated, primarily by renal excretion." @default.
- NCIT_C97466 NCIT_NHC0 "C97466" @default.
- NCIT_C97466 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C97466 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C97466 NCIT_P107 "Pegloticase" @default.
- NCIT_C97466 NCIT_P108 "Pegloticase" @default.
- NCIT_C97466 NCIT_P207 "C2350656" @default.
- NCIT_C97466 NCIT_P210 "885051-90-1" @default.
- NCIT_C97466 NCIT_P319 "R581OT55EA" @default.
- NCIT_C97466 NCIT_P322 "CTRP" @default.
- NCIT_C97466 NCIT_P322 "FDA" @default.
- NCIT_C97466 NCIT_P399 "804942" @default.
- NCIT_C97466 normalizedInformationContent "100" @default.
- NCIT_C97466 referenceCount "1" @default.
- NCIT_C97466 hasExactSynonym "Des-(1-6)-(7-threonine,46-threonine,291-lysine,301-serine)uricase (EC 1.7.3.3, urate oxidase) Sus scrofa (pig) tetramer, Non Acetylated, Carbamates with alpha-carboxy-omega-methoxypoly(oxyethylene)" @default.
- NCIT_C97466 hasExactSynonym "Krystexxa" @default.
- NCIT_C97466 hasExactSynonym "Methoxypolyethylene Glycol Uricase" @default.
- NCIT_C97466 hasExactSynonym "Oxidase, Urate (Synthetic Sus scrofa variant pigks-DN subunit), homotetramer, amide with alpha-carboxy-omega-methoxypoly(oxy-1,2-ethanediyl)" @default.
- NCIT_C97466 hasExactSynonym "PEGLOTICASE" @default.
- NCIT_C97466 hasExactSynonym "Pegloticase" @default.
- NCIT_C97466 hasExactSynonym "Polyethylene Glycol-uricase" @default.
- NCIT_C97466 hasExactSynonym "Puricase" @default.
- NCIT_C97466 inSubset NCIT_C116977 @default.
- NCIT_C97466 inSubset NCIT_C116978 @default.
- NCIT_C97466 inSubset NCIT_C176424 @default.
- NCIT_C97466 inSubset NCIT_C63923 @default.
- NCIT_C97466 type Class @default.
- NCIT_C97466 isDefinedBy ncit.owl @default.
- NCIT_C97466 label "Pegloticase" @default.
- NCIT_C97466 subClassOf NCIT_C1908 @default.
- NCIT_C97466 subClassOf NCIT_C1909 @default.
- NCIT_C97466 subClassOf NCIT_C26170 @default.
- NCIT_C97466 subClassOf NCIT_C921 @default.
- NCIT_C97466 subClassOf NCIT_C97466 @default.