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- NCIT_C97507 IAO_0000115 "An orally available human chemokine receptor 2 (CCR2) antagonist with potential immunomodulating and antineoplastic activities. Upon oral administration, CCR2 antagonist PF-04136309 specifically binds to CCR2 and prevents binding of the endothelium-derived chemokine ligand CLL2 (monocyte chemoattractant protein-1 or MCP1) to its receptor CCR2, which may result in inhibition of CCR2 activation and signal transduction. This may inhibit inflammatory processes as well as angiogenesis, tumor cell migration, and tumor cell proliferation. The G-protein coupled receptor CCR2 is expressed on the surface of monocytes and macrophages, stimulates the migration and infiltration of these cell types, and plays an important role in inflammation, angiogenesis, and tumor cell migration and proliferation." @default.
- NCIT_C97507 NCIT_A32 NCIT_C1909 @default.
- NCIT_C97507 NCIT_A7 NCIT_C101579 @default.
- NCIT_C97507 NCIT_NHC0 "C97507" @default.
- NCIT_C97507 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C97507 NCIT_P107 "CCR2 Antagonist PF-04136309" @default.
- NCIT_C97507 NCIT_P108 "CCR2 Antagonist PF-04136309" @default.
- NCIT_C97507 NCIT_P208 "CL430252" @default.
- NCIT_C97507 NCIT_P210 "1341224-83-6" @default.
- NCIT_C97507 NCIT_P319 "3M2595V4KT" @default.
- NCIT_C97507 NCIT_P322 "CTRP" @default.
- NCIT_C97507 NCIT_P322 "FDA" @default.
- NCIT_C97507 NCIT_P322 "GDC" @default.
- NCIT_C97507 NCIT_P329 "703421" @default.
- NCIT_C97507 NCIT_P330 "703421" @default.
- NCIT_C97507 NCIT_P375 "CCR2 Antagonist PF-04136309" @default.
- NCIT_C97507 NCIT_P399 "703421" @default.
- NCIT_C97507 normalizedInformationContent "100" @default.
- NCIT_C97507 referenceCount "1" @default.
- NCIT_C97507 hasExactSynonym "CCR2 Antagonist PF-04136309" @default.
- NCIT_C97507 hasExactSynonym "PF-04136309" @default.
- NCIT_C97507 hasExactSynonym "PF-4136309" @default.
- NCIT_C97507 inSubset NCIT_C116977 @default.
- NCIT_C97507 inSubset NCIT_C116978 @default.
- NCIT_C97507 inSubset NCIT_C128784 @default.
- NCIT_C97507 inSubset NCIT_C157711 @default.
- NCIT_C97507 inSubset NCIT_C157712 @default.
- NCIT_C97507 inSubset NCIT_C176424 @default.
- NCIT_C97507 inSubset NCIT_C177537 @default.
- NCIT_C97507 inSubset NCIT_C63923 @default.
- NCIT_C97507 type Class @default.
- NCIT_C97507 isDefinedBy ncit.owl @default.
- NCIT_C97507 label "CCR2 Antagonist PF-04136309" @default.
- NCIT_C97507 subClassOf NCIT_C1908 @default.
- NCIT_C97507 subClassOf NCIT_C1909 @default.
- NCIT_C97507 subClassOf NCIT_C308 @default.
- NCIT_C97507 subClassOf NCIT_C63817 @default.
- NCIT_C97507 subClassOf NCIT_C97507 @default.