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- NCIT_C97513 IAO_0000115 "A topical formulation containing the histone deacetylase (HDAC) inhibitor with potential antineoplastic activity. Upon cutaneous administration, SHP-141 selectively binds to and inhibits HDAC, resulting in an accumulation of highly acetylated histones in the skin (dermis and epidermis), the induction of chromatin remodeling, and the selective transcription of tumor suppressor genes. These events may result in the inhibition of tumor cell division and the induction of tumor cell apoptosis. HDACs, upregulated in many tumor cell types, are a family of metalloenzymes responsible for the deacetylation of chromatin histone proteins. Topical administration of SHP-141 allows for high concentrations of this agent locally while minimizing systemic toxicity." @default.
- NCIT_C97513 NCIT_A32 NCIT_C1909 @default.
- NCIT_C97513 NCIT_A7 NCIT_C16682 @default.
- NCIT_C97513 NCIT_NHC0 "C97513" @default.
- NCIT_C97513 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C97513 NCIT_P107 "Remetinostat" @default.
- NCIT_C97513 NCIT_P108 "Remetinostat" @default.
- NCIT_C97513 NCIT_P208 "CL430257" @default.
- NCIT_C97513 NCIT_P210 "946150-57-8" @default.
- NCIT_C97513 NCIT_P319 "37NT056AT4" @default.
- NCIT_C97513 NCIT_P322 "CTRP" @default.
- NCIT_C97513 NCIT_P322 "FDA" @default.
- NCIT_C97513 NCIT_P322 "GDC" @default.
- NCIT_C97513 NCIT_P329 "703816" @default.
- NCIT_C97513 NCIT_P330 "703816" @default.
- NCIT_C97513 NCIT_P375 "Remetinostat" @default.
- NCIT_C97513 NCIT_P399 "703816" @default.
- NCIT_C97513 normalizedInformationContent "100" @default.
- NCIT_C97513 referenceCount "1" @default.
- NCIT_C97513 hasExactSynonym "Methyl 4-((8-(Hydroxyamino)-8-Oxooctanoyl)oxy)benzoate" @default.
- NCIT_C97513 hasExactSynonym "Methylparaben Suberohydroxamic Acid Phenyl Ester" @default.
- NCIT_C97513 hasExactSynonym "REMETINOSTAT" @default.
- NCIT_C97513 hasExactSynonym "Remetinostat" @default.
- NCIT_C97513 hasExactSynonym "SHAPE" @default.
- NCIT_C97513 hasExactSynonym "SHP-141" @default.
- NCIT_C97513 inSubset NCIT_C116977 @default.
- NCIT_C97513 inSubset NCIT_C116978 @default.
- NCIT_C97513 inSubset NCIT_C128784 @default.
- NCIT_C97513 inSubset NCIT_C157711 @default.
- NCIT_C97513 inSubset NCIT_C157712 @default.
- NCIT_C97513 inSubset NCIT_C176424 @default.
- NCIT_C97513 inSubset NCIT_C177537 @default.
- NCIT_C97513 inSubset NCIT_C63923 @default.
- NCIT_C97513 type Class @default.
- NCIT_C97513 isDefinedBy ncit.owl @default.
- NCIT_C97513 label "Remetinostat" @default.
- NCIT_C97513 subClassOf NCIT_C129824 @default.
- NCIT_C97513 subClassOf NCIT_C129825 @default.
- NCIT_C97513 subClassOf NCIT_C163758 @default.
- NCIT_C97513 subClassOf NCIT_C1908 @default.
- NCIT_C97513 subClassOf NCIT_C1909 @default.
- NCIT_C97513 subClassOf NCIT_C1946 @default.
- NCIT_C97513 subClassOf NCIT_C2189 @default.
- NCIT_C97513 subClassOf NCIT_C274 @default.
- NCIT_C97513 subClassOf NCIT_C471 @default.
- NCIT_C97513 subClassOf NCIT_C97513 @default.