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- NCIT_C97660 IAO_0000115 "An orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. Abemaciclib specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation in early G1. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of the serine/threonine kinases CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation." @default.
- NCIT_C97660 NCIT_A32 NCIT_C1909 @default.
- NCIT_C97660 NCIT_NHC0 "C97660" @default.
- NCIT_C97660 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C97660 NCIT_P108 "Abemaciclib" @default.
- NCIT_C97660 NCIT_P207 "C3852841" @default.
- NCIT_C97660 NCIT_P210 "1231929-97-7" @default.
- NCIT_C97660 NCIT_P302 "hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer" @default.
- NCIT_C97660 NCIT_P319 "60UAB198HK" @default.
- NCIT_C97660 NCIT_P322 "FDA" @default.
- NCIT_C97660 NCIT_P322 "GDC" @default.
- NCIT_C97660 NCIT_P329 "706364" @default.
- NCIT_C97660 NCIT_P330 "706364" @default.
- NCIT_C97660 NCIT_P375 "Abemaciclib" @default.
- NCIT_C97660 NCIT_P399 "706364" @default.
- NCIT_C97660 normalizedInformationContent "86.239998175184226" @default.
- NCIT_C97660 referenceCount "8" @default.
- NCIT_C97660 hasExactSynonym "2-Pyrimidinamine, N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)" @default.
- NCIT_C97660 hasExactSynonym "ABEMACICLIB" @default.
- NCIT_C97660 hasExactSynonym "Abemaciclib" @default.
- NCIT_C97660 hasExactSynonym "LY-2835219" @default.
- NCIT_C97660 hasExactSynonym "LY2835219" @default.
- NCIT_C97660 hasExactSynonym "Verzenio" @default.
- NCIT_C97660 inSubset NCIT_C128784 @default.
- NCIT_C97660 inSubset NCIT_C157711 @default.
- NCIT_C97660 inSubset NCIT_C157712 @default.
- NCIT_C97660 inSubset NCIT_C176424 @default.
- NCIT_C97660 inSubset NCIT_C177537 @default.
- NCIT_C97660 inSubset NCIT_C63923 @default.
- NCIT_C97660 type Class @default.
- NCIT_C97660 isDefinedBy ncit.owl @default.
- NCIT_C97660 label "Abemaciclib" @default.
- NCIT_C97660 subClassOf NCIT_C129824 @default.
- NCIT_C97660 subClassOf NCIT_C129825 @default.
- NCIT_C97660 subClassOf NCIT_C1404 @default.
- NCIT_C97660 subClassOf NCIT_C163758 @default.
- NCIT_C97660 subClassOf NCIT_C1908 @default.
- NCIT_C97660 subClassOf NCIT_C1909 @default.
- NCIT_C97660 subClassOf NCIT_C192741 @default.
- NCIT_C97660 subClassOf NCIT_C192742 @default.
- NCIT_C97660 subClassOf NCIT_C2185 @default.
- NCIT_C97660 subClassOf NCIT_C2189 @default.
- NCIT_C97660 subClassOf NCIT_C274 @default.
- NCIT_C97660 subClassOf NCIT_C471 @default.
- NCIT_C97660 subClassOf NCIT_C61074 @default.
- NCIT_C97660 subClassOf NCIT_C97660 @default.