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- NCIT_C978 IAO_0000115 "A fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designed to circumvent the rapid degradation of 5-FU by dihydropyrimidine dehydrogenase in the gut wall, is converted into 5-FU in the presence of pyrimidine nucleoside phosphorylase. 5-FU interferes with DNA synthesis and subsequent cell division by reducing normal thymidine production and interferes with RNA transcription by competing with uridine triphosphate for incorporation into the RNA strand." @default.
- NCIT_C978 NCIT_A32 NCIT_C1909 @default.
- NCIT_C978 NCIT_NHC0 "C978" @default.
- NCIT_C978 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C978 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C978 NCIT_P108 "Doxifluridine" @default.
- NCIT_C978 NCIT_P207 "C0048808" @default.
- NCIT_C978 NCIT_P210 "3094-09-5" @default.
- NCIT_C978 NCIT_P319 "V1JK16Y2JP" @default.
- NCIT_C978 NCIT_P322 "FDA" @default.
- NCIT_C978 NCIT_P322 "GDC" @default.
- NCIT_C978 NCIT_P329 "481255" @default.
- NCIT_C978 NCIT_P330 "481255" @default.
- NCIT_C978 NCIT_P350 "C9H11FN2O5" @default.
- NCIT_C978 NCIT_P366 "Doxifluridine" @default.
- NCIT_C978 NCIT_P375 "Doxifluridine" @default.
- NCIT_C978 NCIT_P399 "481255" @default.
- NCIT_C978 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C978 referenceCount "2" @default.
- NCIT_C978 hasExactSynonym "5'-Deoxy-5-fluorouridine" @default.
- NCIT_C978 hasExactSynonym "5-DFUR" @default.
- NCIT_C978 hasExactSynonym "DOXIFLURIDINE" @default.
- NCIT_C978 hasExactSynonym "Doxifluridine" @default.
- NCIT_C978 inSubset NCIT_C128784 @default.
- NCIT_C978 inSubset NCIT_C157711 @default.
- NCIT_C978 inSubset NCIT_C157712 @default.
- NCIT_C978 inSubset NCIT_C176424 @default.
- NCIT_C978 inSubset NCIT_C177537 @default.
- NCIT_C978 inSubset NCIT_C63923 @default.
- NCIT_C978 type Class @default.
- NCIT_C978 isDefinedBy ncit.owl @default.
- NCIT_C978 label "Doxifluridine" @default.
- NCIT_C978 subClassOf NCIT_C1557 @default.
- NCIT_C978 subClassOf NCIT_C186664 @default.
- NCIT_C978 subClassOf NCIT_C1908 @default.
- NCIT_C978 subClassOf NCIT_C1909 @default.
- NCIT_C978 subClassOf NCIT_C272 @default.
- NCIT_C978 subClassOf NCIT_C274 @default.
- NCIT_C978 subClassOf NCIT_C978 @default.