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- NCIT_C97959 IAO_0000115 "A replication incompetent adenovirus encoding the human pro-inflammatory cytokine interleukin-12 (IL-12) (INXN-2001) in combination with the proprietary activator ligand INXN-1001, with potential immunomodulating and antineoplastic activities. Production of IL-12 is controlled by an inducible DNA element that allows transcription initiation only in the presence of the ligand inducer. Upon intratumoral administration of INXN-2001 and oral administration of INXN-1001, INXN-1001 is able to induce expression of IL-12 from INXN-2001. IL-12 expressed by the adenovirus may activate the immune system by promoting the activation of natural killer cells (NKs), inducing secretion of interferon-gamma and inducing cytotoxic T cell responses against tumor cells, which may result in immune-mediated tumor cell death and inhibition of tumor cell proliferation." @default.
- NCIT_C97959 NCIT_A32 NCIT_C1909 @default.
- NCIT_C97959 NCIT_A7 NCIT_C38917 @default.
- NCIT_C97959 NCIT_A7 NCIT_C38919 @default.
- NCIT_C97959 NCIT_NHC0 "C97959" @default.
- NCIT_C97959 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C97959 NCIT_P107 "Adenovirus-mediated Human Interleukin-12 INXN-2001 Plus Activator Ligand INXN-1001" @default.
- NCIT_C97959 NCIT_P108 "Adenovirus-mediated Human Interleukin-12 INXN-2001 Plus Activator Ligand INXN-1001" @default.
- NCIT_C97959 NCIT_P208 "CL430563" @default.
- NCIT_C97959 NCIT_P322 "CTRP" @default.
- NCIT_C97959 NCIT_P322 "GDC" @default.
- NCIT_C97959 NCIT_P329 "710508" @default.
- NCIT_C97959 NCIT_P330 "710508" @default.
- NCIT_C97959 NCIT_P375 "Adenovirus-mediated Human Interleukin-12 INXN-2001 Plus Activator Ligand INXN-1001" @default.
- NCIT_C97959 NCIT_P399 "710508" @default.
- NCIT_C97959 normalizedInformationContent "100" @default.
- NCIT_C97959 referenceCount "1" @default.
- NCIT_C97959 hasExactSynonym "Ad-RTS-IL-12 Plus AL" @default.
- NCIT_C97959 hasExactSynonym "Adenovirus-mediated Human Interleukin-12 INXN-2001 Plus Activator Ligand INXN-1001" @default.
- NCIT_C97959 hasExactSynonym "INXN-2001/1001" @default.
- NCIT_C97959 hasExactSynonym "ZIN ATI-001" @default.
- NCIT_C97959 inSubset NCIT_C116977 @default.
- NCIT_C97959 inSubset NCIT_C116978 @default.
- NCIT_C97959 inSubset NCIT_C128784 @default.
- NCIT_C97959 inSubset NCIT_C157711 @default.
- NCIT_C97959 inSubset NCIT_C157712 @default.
- NCIT_C97959 inSubset NCIT_C176424 @default.
- NCIT_C97959 inSubset NCIT_C177537 @default.
- NCIT_C97959 type Class @default.
- NCIT_C97959 isDefinedBy ncit.owl @default.
- NCIT_C97959 label "Adenovirus-mediated Human Interleukin-12 INXN-2001 Plus Activator Ligand INXN-1001" @default.
- NCIT_C97959 subClassOf NCIT_C129820 @default.
- NCIT_C97959 subClassOf NCIT_C1908 @default.
- NCIT_C97959 subClassOf NCIT_C1909 @default.
- NCIT_C97959 subClassOf NCIT_C1962 @default.
- NCIT_C97959 subClassOf NCIT_C274 @default.
- NCIT_C97959 subClassOf NCIT_C307 @default.
- NCIT_C97959 subClassOf NCIT_C308 @default.
- NCIT_C97959 subClassOf NCIT_C61199 @default.
- NCIT_C97959 subClassOf NCIT_C97959 @default.