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- NCIT_C97961 IAO_0000115 "A fusion protein consisting of the heavy-chains of the human antibody NHS76, raised against DNA released by necrotic tumor cells, and fused to two molecules of a genetically modified human interleukin-12 (IL-12) with potential immunostimulating and antineoplastic activities. Upon administration, the antibody moiety of immunocytokine NHS-IL12 binds to DNA released from necrotic tumor cells located primarily at the core of necrotic solid tumors, thereby delivering the IL-12 moiety. In turn, the IL-12 moiety of this agent stimulates the host immune system to mount an immune response against tumor cells, thereby inhibiting tumor growth. IL-12 is a proinflammatory cytokine with numerous immunoregulatory functions and may augment host immune responses to tumor cells. By targeting tumor cells, NHS-IL-12 may reduce the toxicity associated with systemic administration of recombinant human IL-12." @default.
- NCIT_C97961 NCIT_A32 NCIT_C1909 @default.
- NCIT_C97961 NCIT_NHC0 "C97961" @default.
- NCIT_C97961 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C97961 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C97961 NCIT_P107 "Immunocytokine NHS-IL12" @default.
- NCIT_C97961 NCIT_P108 "Immunocytokine NHS-IL12" @default.
- NCIT_C97961 NCIT_P207 "C3273725" @default.
- NCIT_C97961 NCIT_P210 "1807503-77-0" @default.
- NCIT_C97961 NCIT_P319 "KF6D9Z1MER" @default.
- NCIT_C97961 NCIT_P322 "CTRP" @default.
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- NCIT_C97961 NCIT_P329 "710539" @default.
- NCIT_C97961 NCIT_P330 "710539" @default.
- NCIT_C97961 NCIT_P375 "Immunocytokine NHS-IL12" @default.
- NCIT_C97961 NCIT_P399 "710539" @default.
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- NCIT_C97961 normalizedInformationContent "100" @default.
- NCIT_C97961 referenceCount "1" @default.
- NCIT_C97961 hasExactSynonym "IMMUNOCYTOKINE NHS-IL12" @default.
- NCIT_C97961 hasExactSynonym "Immunocytokine NHS-IL12" @default.
- NCIT_C97961 hasExactSynonym "M-9241" @default.
- NCIT_C97961 hasExactSynonym "M9241" @default.
- NCIT_C97961 hasExactSynonym "NHS-IL-12" @default.
- NCIT_C97961 hasExactSynonym "NHS-IL12" @default.
- NCIT_C97961 inSubset NCIT_C116977 @default.
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- NCIT_C97961 type Class @default.
- NCIT_C97961 isDefinedBy ncit.owl @default.
- NCIT_C97961 label "Immunocytokine NHS-IL12" @default.
- NCIT_C97961 subClassOf B6401d9ef7ec9ceba90115c08fee2a40b @default.
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