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- NCIT_C98250 IAO_0000115 "The methyl ester form of bardoxolone, a synthetic triterpenoid compound with potential antineoplastic and anti-inflammatory activities. Bardoxolone blocks the synthesis of inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2), two enzymes involved in inflammation and carcinogenesis. This agent also inhibits the interleukin-1 (IL-1)-induced expression of the pro-inflammatory proteins matrix metalloproteinase-1 (MMP-1) and matrix metalloproteinase-13 (MMP-13) and the expression of Bcl-3; Bcl-3 is an IL-1-responsive gene that preferentially contributes to MMP-1 gene expression." @default.
- NCIT_C98250 NCIT_A32 NCIT_C1909 @default.
- NCIT_C98250 NCIT_A7 NCIT_C17984 @default.
- NCIT_C98250 NCIT_A7 NCIT_C38565 @default.
- NCIT_C98250 NCIT_NHC0 "C98250" @default.
- NCIT_C98250 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C98250 NCIT_P107 "Bardoxolone Methyl" @default.
- NCIT_C98250 NCIT_P108 "Bardoxolone Methyl" @default.
- NCIT_C98250 NCIT_P175 "713200" @default.
- NCIT_C98250 NCIT_P207 "C1100924" @default.
- NCIT_C98250 NCIT_P210 "218600-53-4" @default.
- NCIT_C98250 NCIT_P319 "CEG1Q6OGU1" @default.
- NCIT_C98250 NCIT_P322 "CTRP" @default.
- NCIT_C98250 NCIT_P322 "FDA" @default.
- NCIT_C98250 NCIT_P322 "GDC" @default.
- NCIT_C98250 NCIT_P350 "C32H43NO4" @default.
- NCIT_C98250 NCIT_P375 "Bardoxolone Methyl" @default.
- NCIT_C98250 normalizedInformationContent "100" @default.
- NCIT_C98250 referenceCount "1" @default.
- NCIT_C98250 hasExactSynonym "(+)-methyl 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate" @default.
- NCIT_C98250 hasExactSynonym "2-cyano-3,12-dioxoolean-1,9-dien-28-oic Acid Methyl Ester" @default.
- NCIT_C98250 hasExactSynonym "BARDOXOLONE METHYL" @default.
- NCIT_C98250 hasExactSynonym "Bardoxolone Methyl" @default.
- NCIT_C98250 hasExactSynonym "CDDO Methyl Ester" @default.
- NCIT_C98250 hasExactSynonym "CDDO-Me" @default.
- NCIT_C98250 hasExactSynonym "RTA 402" @default.
- NCIT_C98250 inSubset NCIT_C116977 @default.
- NCIT_C98250 inSubset NCIT_C116978 @default.
- NCIT_C98250 inSubset NCIT_C128784 @default.
- NCIT_C98250 inSubset NCIT_C157711 @default.
- NCIT_C98250 inSubset NCIT_C157712 @default.
- NCIT_C98250 inSubset NCIT_C173381 @default.
- NCIT_C98250 inSubset NCIT_C173383 @default.
- NCIT_C98250 inSubset NCIT_C177537 @default.
- NCIT_C98250 inSubset NCIT_C63923 @default.
- NCIT_C98250 type Class @default.
- NCIT_C98250 isDefinedBy ncit.owl @default.
- NCIT_C98250 label "Bardoxolone Methyl" @default.
- NCIT_C98250 subClassOf NCIT_C1323 @default.
- NCIT_C98250 subClassOf NCIT_C1908 @default.
- NCIT_C98250 subClassOf NCIT_C1909 @default.
- NCIT_C98250 subClassOf NCIT_C2198 @default.
- NCIT_C98250 subClassOf NCIT_C2356 @default.
- NCIT_C98250 subClassOf NCIT_C241 @default.
- NCIT_C98250 subClassOf NCIT_C257 @default.
- NCIT_C98250 subClassOf NCIT_C29574 @default.
- NCIT_C98250 subClassOf NCIT_C471 @default.
- NCIT_C98250 subClassOf NCIT_C78272 @default.
- NCIT_C98250 subClassOf NCIT_C98250 @default.