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- NCIT_C98282 IAO_0000115 "An allogeneic cancer vaccine composed of lethally irradiated whole melanoma cancer cells that are genetically modified to secrete the immunostimulatory cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF), with potential immunostimulating and antineoplastic activities. Upon intradermal injections, allogeneic GM-CSF-secreting lethally irradiated whole melanoma cell vaccine secretes GM-CSF. In turn, GM-CSF may stimulate the body's immune system against tumor cells by enhancing the activation of dendritic cells (DCs) and promoting antigen presentation to both B- and T-lymphocytes. In addition, GM-CSF promotes antibody-dependent cellular cytotoxicity (ADCC), and increases interleukin-2-mediated lymphokine-activated killer cell function." @default.
- NCIT_C98282 NCIT_A32 NCIT_C1909 @default.
- NCIT_C98282 NCIT_NHC0 "C98282" @default.
- NCIT_C98282 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C98282 NCIT_P107 "Allogeneic GM-CSF-secreting Lethally Irradiated Whole Melanoma Cell Vaccine" @default.
- NCIT_C98282 NCIT_P108 "Allogeneic GM-CSF-secreting Lethally Irradiated Whole Melanoma Cell Vaccine" @default.
- NCIT_C98282 NCIT_P208 "CL432401" @default.
- NCIT_C98282 NCIT_P322 "CTRP" @default.
- NCIT_C98282 NCIT_P322 "GDC" @default.
- NCIT_C98282 NCIT_P329 "712484" @default.
- NCIT_C98282 NCIT_P330 "712484" @default.
- NCIT_C98282 NCIT_P375 "Allogeneic GM-CSF-secreting Lethally Irradiated Whole Melanoma Cell Vaccine" @default.
- NCIT_C98282 NCIT_P399 "712484" @default.
- NCIT_C98282 normalizedInformationContent "100" @default.
- NCIT_C98282 referenceCount "1" @default.
- NCIT_C98282 hasExactSynonym "Allogeneic GM-CSF-secreting Lethally Irradiated Whole Melanoma Cell Vaccine" @default.
- NCIT_C98282 hasExactSynonym "GVAX Melanoma Vaccine" @default.
- NCIT_C98282 inSubset NCIT_C116977 @default.
- NCIT_C98282 inSubset NCIT_C116978 @default.
- NCIT_C98282 inSubset NCIT_C128784 @default.
- NCIT_C98282 inSubset NCIT_C157711 @default.
- NCIT_C98282 inSubset NCIT_C157712 @default.
- NCIT_C98282 inSubset NCIT_C176424 @default.
- NCIT_C98282 inSubset NCIT_C177537 @default.
- NCIT_C98282 type Class @default.
- NCIT_C98282 isDefinedBy ncit.owl @default.
- NCIT_C98282 label "Allogeneic GM-CSF-secreting Lethally Irradiated Whole Melanoma Cell Vaccine" @default.
- NCIT_C98282 subClassOf NCIT_C129820 @default.
- NCIT_C98282 subClassOf NCIT_C1663 @default.
- NCIT_C98282 subClassOf NCIT_C1908 @default.
- NCIT_C98282 subClassOf NCIT_C1909 @default.
- NCIT_C98282 subClassOf NCIT_C2517 @default.
- NCIT_C98282 subClassOf NCIT_C274 @default.
- NCIT_C98282 subClassOf NCIT_C307 @default.
- NCIT_C98282 subClassOf NCIT_C308 @default.
- NCIT_C98282 subClassOf NCIT_C923 @default.
- NCIT_C98282 subClassOf NCIT_C98282 @default.