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- NCIT_C98283 IAO_0000115 "An orally available Raf kinase inhibitor with potential antineoplastic activity. Encorafenib specifically inhibits Raf kinase, a serine/threonine enzyme in the RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-related kinase (ERK) signaling pathway. By inhibiting the activation of the RAF/MEK/ERK signaling pathway, the administration of LGX818 may result in a decrease in proliferation of tumor cells. The Raf mutation BRAF V600E is frequently upregulated in a variety of human tumors and results in the constitutive activation of the RAF/MEK/ERK signaling pathway that regulates cellular proliferation and survival." @default.
- NCIT_C98283 NCIT_A32 NCIT_C1909 @default.
- NCIT_C98283 NCIT_A7 NCIT_C17476 @default.
- NCIT_C98283 NCIT_NHC0 "C98283" @default.
- NCIT_C98283 NCIT_P106 "Organic Chemical" @default.
- NCIT_C98283 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C98283 NCIT_P107 "Encorafenib" @default.
- NCIT_C98283 NCIT_P108 "Encorafenib" @default.
- NCIT_C98283 NCIT_P207 "C4079208" @default.
- NCIT_C98283 NCIT_P210 "1269440-17-6" @default.
- NCIT_C98283 NCIT_P302 "in combination with binimetinib, for the treatment of patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation" @default.
- NCIT_C98283 NCIT_P319 "8L7891MRB6" @default.
- NCIT_C98283 NCIT_P322 "CTRP" @default.
- NCIT_C98283 NCIT_P322 "FDA" @default.
- NCIT_C98283 NCIT_P322 "GDC" @default.
- NCIT_C98283 NCIT_P329 "712549" @default.
- NCIT_C98283 NCIT_P330 "712549" @default.
- NCIT_C98283 NCIT_P375 "Encorafenib" @default.
- NCIT_C98283 NCIT_P399 "712549" @default.
- NCIT_C98283 normalizedInformationContent "87.123597049860606" @default.
- NCIT_C98283 referenceCount "7" @default.
- NCIT_C98283 hasExactSynonym "Braftovi" @default.
- NCIT_C98283 hasExactSynonym "ENCORAFENIB" @default.
- NCIT_C98283 hasExactSynonym "Encorafenib" @default.
- NCIT_C98283 hasExactSynonym "LGX 818" @default.
- NCIT_C98283 hasExactSynonym "LGX-818" @default.
- NCIT_C98283 hasExactSynonym "LGX818" @default.
- NCIT_C98283 inSubset NCIT_C116977 @default.
- NCIT_C98283 inSubset NCIT_C116978 @default.
- NCIT_C98283 inSubset NCIT_C128784 @default.
- NCIT_C98283 inSubset NCIT_C157711 @default.
- NCIT_C98283 inSubset NCIT_C157712 @default.
- NCIT_C98283 inSubset NCIT_C176424 @default.
- NCIT_C98283 inSubset NCIT_C177537 @default.
- NCIT_C98283 inSubset NCIT_C63923 @default.
- NCIT_C98283 type Class @default.
- NCIT_C98283 isDefinedBy ncit.owl @default.
- NCIT_C98283 label "Encorafenib" @default.
- NCIT_C98283 subClassOf NCIT_C129824 @default.
- NCIT_C98283 subClassOf NCIT_C129825 @default.
- NCIT_C98283 subClassOf NCIT_C1404 @default.
- NCIT_C98283 subClassOf NCIT_C155322 @default.
- NCIT_C98283 subClassOf NCIT_C163758 @default.
- NCIT_C98283 subClassOf NCIT_C1908 @default.
- NCIT_C98283 subClassOf NCIT_C1909 @default.
- NCIT_C98283 subClassOf NCIT_C2189 @default.
- NCIT_C98283 subClassOf NCIT_C2336 @default.
- NCIT_C98283 subClassOf NCIT_C274 @default.
- NCIT_C98283 subClassOf NCIT_C471 @default.
- NCIT_C98283 subClassOf NCIT_C61074 @default.
- NCIT_C98283 subClassOf NCIT_C98283 @default.