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- NCIT_C98290 IAO_0000115 "An orally available, vitamin E derivative and androgen receptor (AR) antagonist with potential anti-oxidant, chemopreventative and antineoplastic activity. APC-100 binds to ARs in target tissues thereby inhibiting androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. By inhibiting the formation of the complex between androgen activated AR- and the AP1 transcription factor JunD, the expression of androgen-responsive genes are blocked. One of such gene is spermidine/spermine N1-acetyl transferase gene (SSAT) that is responsible for the breakdown of polyamines, which are produced in high levels by prostatic epithelial cells, into reactive oxygen species (ROS) that cause cellular damage. APC-100 may ultimately lead to an inhibition of growth in both AR-dependent and AR-independent prostate tumor cells." @default.
- NCIT_C98290 NCIT_A32 NCIT_C1909 @default.
- NCIT_C98290 NCIT_A7 NCIT_C17063 @default.
- NCIT_C98290 NCIT_NHC0 "C98290" @default.
- NCIT_C98290 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C98290 NCIT_P107 "Androgen Antagonist APC-100" @default.
- NCIT_C98290 NCIT_P108 "Androgen Antagonist APC-100" @default.
- NCIT_C98290 NCIT_P208 "CL432408" @default.
- NCIT_C98290 NCIT_P210 "950-99-2" @default.
- NCIT_C98290 NCIT_P319 "7G73627R36" @default.
- NCIT_C98290 NCIT_P322 "CTRP" @default.
- NCIT_C98290 NCIT_P322 "FDA" @default.
- NCIT_C98290 NCIT_P322 "GDC" @default.
- NCIT_C98290 NCIT_P329 "712831" @default.
- NCIT_C98290 NCIT_P330 "712831" @default.
- NCIT_C98290 NCIT_P375 "Androgen Antagonist APC-100" @default.
- NCIT_C98290 NCIT_P399 "712831" @default.
- NCIT_C98290 normalizedInformationContent "100" @default.
- NCIT_C98290 referenceCount "1" @default.
- NCIT_C98290 hasExactSynonym "APC-100" @default.
- NCIT_C98290 hasExactSynonym "Androgen Antagonist APC-100" @default.
- NCIT_C98290 hasExactSynonym "CHROMANOL" @default.
- NCIT_C98290 inSubset NCIT_C116977 @default.
- NCIT_C98290 inSubset NCIT_C116978 @default.
- NCIT_C98290 inSubset NCIT_C128784 @default.
- NCIT_C98290 inSubset NCIT_C157711 @default.
- NCIT_C98290 inSubset NCIT_C157712 @default.
- NCIT_C98290 inSubset NCIT_C176424 @default.
- NCIT_C98290 inSubset NCIT_C177537 @default.
- NCIT_C98290 inSubset NCIT_C63923 @default.
- NCIT_C98290 type Class @default.
- NCIT_C98290 isDefinedBy ncit.owl @default.
- NCIT_C98290 label "Androgen Antagonist APC-100" @default.
- NCIT_C98290 subClassOf NCIT_C146993 @default.
- NCIT_C98290 subClassOf NCIT_C147908 @default.
- NCIT_C98290 subClassOf NCIT_C163758 @default.
- NCIT_C98290 subClassOf NCIT_C1908 @default.
- NCIT_C98290 subClassOf NCIT_C1909 @default.
- NCIT_C98290 subClassOf NCIT_C242 @default.
- NCIT_C98290 subClassOf NCIT_C274 @default.
- NCIT_C98290 subClassOf NCIT_C547 @default.
- NCIT_C98290 subClassOf NCIT_C98290 @default.