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- NCIT_C98293 IAO_0000115 "A fully human IgG1 monoclonal antibody directed against the cell surface glycoprotein mesothelin and conjugated to the maytansinoid DM4 with potential antineoplastic activity. The monoclonal antibody moiety of anetumab ravtansine targets and binds to the tumor associated antigen mesothelin; upon internalization, the DM4 moiety binds to tubulin and disrupts microtubule assembly/disassembly dynamics, resulting in inhibition of cell division and cell growth of mesothelin-expressing tumor cells. Mesothelin is overexpressed on all mesotheliomas as well as many ovarian and pancreatic cancers while minimally expressed on normal tissue." @default.
- NCIT_C98293 NCIT_A32 NCIT_C1909 @default.
- NCIT_C98293 NCIT_A7 NCIT_C20887 @default.
- NCIT_C98293 NCIT_NHC0 "C98293" @default.
- NCIT_C98293 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C98293 NCIT_P107 "Anetumab Ravtansine" @default.
- NCIT_C98293 NCIT_P108 "Anetumab Ravtansine" @default.
- NCIT_C98293 NCIT_P207 "C4045305" @default.
- NCIT_C98293 NCIT_P210 "1375258-01-7" @default.
- NCIT_C98293 NCIT_P319 "M170940PMI" @default.
- NCIT_C98293 NCIT_P322 "CTRP" @default.
- NCIT_C98293 NCIT_P322 "FDA" @default.
- NCIT_C98293 NCIT_P322 "GDC" @default.
- NCIT_C98293 NCIT_P329 "712853" @default.
- NCIT_C98293 NCIT_P330 "712853" @default.
- NCIT_C98293 NCIT_P375 "Anetumab Ravtansine" @default.
- NCIT_C98293 NCIT_P399 "712853" @default.
- NCIT_C98293 normalizedInformationContent "100" @default.
- NCIT_C98293 referenceCount "1" @default.
- NCIT_C98293 hasExactSynonym "ANETUMAB RAVTANSINE" @default.
- NCIT_C98293 hasExactSynonym "Anetumab Ravtansine" @default.
- NCIT_C98293 hasExactSynonym "BAY 94-9343" @default.
- NCIT_C98293 inSubset NCIT_C116977 @default.
- NCIT_C98293 inSubset NCIT_C116978 @default.
- NCIT_C98293 inSubset NCIT_C128784 @default.
- NCIT_C98293 inSubset NCIT_C157711 @default.
- NCIT_C98293 inSubset NCIT_C157712 @default.
- NCIT_C98293 inSubset NCIT_C176424 @default.
- NCIT_C98293 inSubset NCIT_C177537 @default.
- NCIT_C98293 inSubset NCIT_C63923 @default.
- NCIT_C98293 type Class @default.
- NCIT_C98293 isDefinedBy ncit.owl @default.
- NCIT_C98293 label "Anetumab Ravtansine" @default.
- NCIT_C98293 subClassOf NCIT_C129821 @default.
- NCIT_C98293 subClassOf NCIT_C129823 @default.
- NCIT_C98293 subClassOf NCIT_C1512 @default.
- NCIT_C98293 subClassOf NCIT_C1908 @default.
- NCIT_C98293 subClassOf NCIT_C1909 @default.
- NCIT_C98293 subClassOf NCIT_C274 @default.
- NCIT_C98293 subClassOf NCIT_C307 @default.
- NCIT_C98293 subClassOf NCIT_C308 @default.
- NCIT_C98293 subClassOf NCIT_C98293 @default.