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- NCIT_C984 IAO_0000115 "A derivative of D-glucaro-1, 4-lactone with chemopreventive and anti-tumor activities. One of the key processes in which human body eliminates toxic chemicals as well as hormones (such as estrogen) is by glucuronidation. When beta-glucuronidase deconjugates these glucuronides, it prolongs the stay of the hormone or toxic chemical in the body. Elevated beta-glucuronidase activity has been implicated to be associated with an increased risk for hormone-dependent cancers like breast, prostate, and colon cancers. Thereby, aceglatone may suppress the developments of hormone-dependent cancers mediated through beta-glucuronidase inhibition." @default.
- NCIT_C984 NCIT_A32 NCIT_C1909 @default.
- NCIT_C984 NCIT_NHC0 "C984" @default.
- NCIT_C984 NCIT_P106 "Organic Chemical" @default.
- NCIT_C984 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C984 NCIT_P108 "Aceglatone" @default.
- NCIT_C984 NCIT_P207 "C0050406" @default.
- NCIT_C984 NCIT_P210 "642-83-1" @default.
- NCIT_C984 NCIT_P319 "347Q3OOJ13" @default.
- NCIT_C984 NCIT_P322 "FDA" @default.
- NCIT_C984 NCIT_P322 "GDC" @default.
- NCIT_C984 NCIT_P350 "C10H10O8" @default.
- NCIT_C984 NCIT_P366 "Aceglatone" @default.
- NCIT_C984 NCIT_P375 "Aceglatone" @default.
- NCIT_C984 normalizedInformationContent "100" @default.
- NCIT_C984 referenceCount "1" @default.
- NCIT_C984 hasExactSynonym "ACEGLATONE" @default.
- NCIT_C984 hasExactSynonym "Aceglatone" @default.
- NCIT_C984 hasExactSynonym "Glucaron" @default.
- NCIT_C984 inSubset NCIT_C128784 @default.
- NCIT_C984 inSubset NCIT_C157711 @default.
- NCIT_C984 inSubset NCIT_C157712 @default.
- NCIT_C984 inSubset NCIT_C177537 @default.
- NCIT_C984 inSubset NCIT_C63923 @default.
- NCIT_C984 type Class @default.
- NCIT_C984 isDefinedBy ncit.owl @default.
- NCIT_C984 label "Aceglatone" @default.
- NCIT_C984 subClassOf NCIT_C1017 @default.
- NCIT_C984 subClassOf NCIT_C1908 @default.
- NCIT_C984 subClassOf NCIT_C1909 @default.
- NCIT_C984 subClassOf NCIT_C471 @default.
- NCIT_C984 subClassOf NCIT_C984 @default.