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- NCIT_C98832 IAO_0000115 "An orally bioavailable small-molecule inhibitor of mitogen-activated protein kinase kinase (MAP2K, MAPK/ERK kinase, or MEK) 1 and 2 with potential antineoplastic activity. MEK1/2 inhibitor AS703988/MSC2015103B selectively binds to and inhibits the activity of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK1/2 are dual-specificity threonine/tyrosine kinases that play key roles in the activation of the RAS/RAF/MEK/ERK pathway that regulates cell growth and are often upregulated in a variety of tumor cell types." @default.
- NCIT_C98832 NCIT_A32 NCIT_C1909 @default.
- NCIT_C98832 NCIT_A7 NCIT_C106633 @default.
- NCIT_C98832 NCIT_A7 NCIT_C17808 @default.
- NCIT_C98832 NCIT_NHC0 "C98832" @default.
- NCIT_C98832 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C98832 NCIT_P107 "MEK 1/2 Inhibitor AS703988/MSC2015103B" @default.
- NCIT_C98832 NCIT_P108 "MEK 1/2 Inhibitor AS703988/MSC2015103B" @default.
- NCIT_C98832 NCIT_P208 "CL432851" @default.
- NCIT_C98832 NCIT_P322 "CTRP" @default.
- NCIT_C98832 NCIT_P322 "GDC" @default.
- NCIT_C98832 NCIT_P329 "714900" @default.
- NCIT_C98832 NCIT_P330 "714900" @default.
- NCIT_C98832 NCIT_P375 "MEK 1/2 Inhibitor AS703988/MSC2015103B" @default.
- NCIT_C98832 NCIT_P399 "714900" @default.
- NCIT_C98832 normalizedInformationContent "100" @default.
- NCIT_C98832 referenceCount "1" @default.
- NCIT_C98832 hasExactSynonym "AS703988" @default.
- NCIT_C98832 hasExactSynonym "AS703988/MSC2015103B" @default.
- NCIT_C98832 hasExactSynonym "MEK 1/2 Inhibitor AS703988/MSC2015103B" @default.
- NCIT_C98832 hasExactSynonym "MSC2015103B" @default.
- NCIT_C98832 inSubset NCIT_C116977 @default.
- NCIT_C98832 inSubset NCIT_C116978 @default.
- NCIT_C98832 inSubset NCIT_C128784 @default.
- NCIT_C98832 inSubset NCIT_C157711 @default.
- NCIT_C98832 inSubset NCIT_C157712 @default.
- NCIT_C98832 inSubset NCIT_C176424 @default.
- NCIT_C98832 inSubset NCIT_C177537 @default.
- NCIT_C98832 type Class @default.
- NCIT_C98832 isDefinedBy ncit.owl @default.
- NCIT_C98832 label "MEK 1/2 Inhibitor AS703988/MSC2015103B" @default.
- NCIT_C98832 subClassOf NCIT_C129824 @default.
- NCIT_C98832 subClassOf NCIT_C129825 @default.
- NCIT_C98832 subClassOf NCIT_C1404 @default.
- NCIT_C98832 subClassOf NCIT_C163758 @default.
- NCIT_C98832 subClassOf NCIT_C1908 @default.
- NCIT_C98832 subClassOf NCIT_C1909 @default.
- NCIT_C98832 subClassOf NCIT_C2189 @default.
- NCIT_C98832 subClassOf NCIT_C274 @default.
- NCIT_C98832 subClassOf NCIT_C471 @default.
- NCIT_C98832 subClassOf NCIT_C69145 @default.
- NCIT_C98832 subClassOf NCIT_C98832 @default.