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- NCIT_C99114 IAO_0000115 "A cancer cell vaccine composed of autologous human Langerhans-type dendritic cells (also known as Langerhans cells or LCs) that are electroporated with mRNA encoding full-length murine tyrosinase-related peptide 2 (TRP2), with potential antineoplastic and immunomodulating activities. Upon vaccination, the TRP2 mRNA-electroporated autologous Langerhans-type dendritic cell vaccine may stimulate the immune system to mount a cytotoxic T-lymphocyte (CTL) response against TRP2-expressing tumor cells. TRP2, a tautomerase involved in the synthesis of melanin, is only expressed in melanomas, melanocytes, and the retina. The LCs are differentiated from CD34 positive hematopoietic progenitor cells." @default.
- NCIT_C99114 NCIT_A7 NCIT_C2646 @default.
- NCIT_C99114 NCIT_NHC0 "C99114" @default.
- NCIT_C99114 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C99114 NCIT_P107 "TRP2 mRNA-electroporated Autologous Langerhans-type Dendritic Cell Vaccine" @default.
- NCIT_C99114 NCIT_P108 "TRP2 mRNA-electroporated Autologous Langerhans-type Dendritic Cell Vaccine" @default.
- NCIT_C99114 NCIT_P208 "CL432936" @default.
- NCIT_C99114 NCIT_P322 "CTRP" @default.
- NCIT_C99114 NCIT_P329 "715579" @default.
- NCIT_C99114 NCIT_P330 "715579" @default.
- NCIT_C99114 NCIT_P399 "715579" @default.
- NCIT_C99114 normalizedInformationContent "100" @default.
- NCIT_C99114 referenceCount "1" @default.
- NCIT_C99114 hasExactSynonym "TRP2 mRNA-electroporated Autologous Langerhans-type Dendritic Cell Vaccine" @default.
- NCIT_C99114 inSubset NCIT_C116977 @default.
- NCIT_C99114 inSubset NCIT_C116978 @default.
- NCIT_C99114 inSubset NCIT_C128784 @default.
- NCIT_C99114 inSubset NCIT_C176424 @default.
- NCIT_C99114 type Class @default.
- NCIT_C99114 isDefinedBy ncit.owl @default.
- NCIT_C99114 label "TRP2 mRNA-electroporated Autologous Langerhans-type Dendritic Cell Vaccine" @default.
- NCIT_C99114 subClassOf NCIT_C129820 @default.
- NCIT_C99114 subClassOf NCIT_C1663 @default.
- NCIT_C99114 subClassOf NCIT_C172787 @default.
- NCIT_C99114 subClassOf NCIT_C181141 @default.
- NCIT_C99114 subClassOf NCIT_C1908 @default.
- NCIT_C99114 subClassOf NCIT_C1909 @default.
- NCIT_C99114 subClassOf NCIT_C274 @default.
- NCIT_C99114 subClassOf NCIT_C28308 @default.
- NCIT_C99114 subClassOf NCIT_C28310 @default.
- NCIT_C99114 subClassOf NCIT_C307 @default.
- NCIT_C99114 subClassOf NCIT_C308 @default.
- NCIT_C99114 subClassOf NCIT_C923 @default.
- NCIT_C99114 subClassOf NCIT_C99114 @default.