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- NCIT_C99127 IAO_0000115 "A human agonistic monoclonal antibody (MoAb) specific for CD27, with potential immunostimulating and antineoplastic activity. Upon administration of varlilumab, this MoAb binds to CD27 and may potentiate the immune response by increasing the cytotoxic T-lymphocyte (CTL) response against CD27-expressing tumor cells. This may lead to growth inhibition of CD27-expressing tumor cells. In addition, this agent may increase the proliferation and activation of antigen-specific T lymphocytes upon co-administration of TAA-containing vaccines, such as dendritic cell vaccines. CD27, a co-stimulatory molecule and member of the tumor necrosis factor family overexpressed in certain tumor cell types, is constitutively expressed on mature T-lymphocytes, memory B cells and natural killer cells and plays an important role in NK cell mediated cytolytic activity and T and B lymphocyte proliferation and activation." @default.
- NCIT_C99127 NCIT_A32 NCIT_C1909 @default.
- NCIT_C99127 NCIT_A7 NCIT_C104073 @default.
- NCIT_C99127 NCIT_NHC0 "C99127" @default.
- NCIT_C99127 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C99127 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C99127 NCIT_P107 "Varlilumab" @default.
- NCIT_C99127 NCIT_P108 "Varlilumab" @default.
- NCIT_C99127 NCIT_P208 "CL432946" @default.
- NCIT_C99127 NCIT_P210 "1393344-72-3" @default.
- NCIT_C99127 NCIT_P319 "0125DUV5XC" @default.
- NCIT_C99127 NCIT_P322 "CTRP" @default.
- NCIT_C99127 NCIT_P322 "FDA" @default.
- NCIT_C99127 NCIT_P322 "GDC" @default.
- NCIT_C99127 NCIT_P329 "715751" @default.
- NCIT_C99127 NCIT_P330 "715751" @default.
- NCIT_C99127 NCIT_P375 "Varlilumab" @default.
- NCIT_C99127 NCIT_P399 "715751" @default.
- NCIT_C99127 NCIT_R124 NCIT_C17710 @default.
- NCIT_C99127 NCIT_R124 NCIT_C17828 @default.
- NCIT_C99127 NCIT_R124 NCIT_C18219 @default.
- NCIT_C99127 NCIT_R124 NCIT_C19986 @default.
- NCIT_C99127 NCIT_R124 NCIT_C40474 @default.
- NCIT_C99127 normalizedInformationContent "100" @default.
- NCIT_C99127 referenceCount "1" @default.
- NCIT_C99127 hasExactSynonym "CDX 1127" @default.
- NCIT_C99127 hasExactSynonym "CDX-1127" @default.
- NCIT_C99127 hasExactSynonym "Immunoglobulin G1, Anti-(Human CD Antigen CD27) (Human Monoclonal CDX-1127 Clone 1f5 Heavy Chain), Disulfide with Human Monoclonal CDX-1127 Clone 1f5 Kappa-chain, Dimer" @default.
- NCIT_C99127 hasExactSynonym "VARLILUMAB" @default.
- NCIT_C99127 hasExactSynonym "Varlilumab" @default.
- NCIT_C99127 inSubset NCIT_C116977 @default.
- NCIT_C99127 inSubset NCIT_C116978 @default.
- NCIT_C99127 inSubset NCIT_C128784 @default.
- NCIT_C99127 inSubset NCIT_C157711 @default.
- NCIT_C99127 inSubset NCIT_C157712 @default.
- NCIT_C99127 inSubset NCIT_C176424 @default.
- NCIT_C99127 inSubset NCIT_C177537 @default.
- NCIT_C99127 inSubset NCIT_C63923 @default.
- NCIT_C99127 type Class @default.
- NCIT_C99127 isDefinedBy ncit.owl @default.
- NCIT_C99127 label "Varlilumab" @default.
- NCIT_C99127 subClassOf NCIT_C129821 @default.
- NCIT_C99127 subClassOf NCIT_C129822 @default.
- NCIT_C99127 subClassOf NCIT_C163758 @default.
- NCIT_C99127 subClassOf NCIT_C1908 @default.
- NCIT_C99127 subClassOf NCIT_C1909 @default.
- NCIT_C99127 subClassOf NCIT_C192186 @default.
- NCIT_C99127 subClassOf NCIT_C201118 @default.
- NCIT_C99127 subClassOf NCIT_C20401 @default.
- NCIT_C99127 subClassOf NCIT_C274 @default.
- NCIT_C99127 subClassOf NCIT_C307 @default.
- NCIT_C99127 subClassOf NCIT_C308 @default.
- NCIT_C99127 subClassOf NCIT_C99127 @default.