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- NCIT_C99131 IAO_0000115 "An orally available, small molecule, antagonist of MDM2 (mouse double minute 2; Mdm2 p53 binding protein homolog), with potential antineoplastic activity. Idasanutlin binds to MDM2 blocking the interaction between the MDM2 protein and the transcriptional activation domain of the tumor suppressor protein p53. By preventing the MDM2-p53 interaction, p53 is not enzymatically degraded and the transcriptional activity of p53 is restored. This may lead to p53-mediated induction of tumor cell apoptosis. MDM2, a zinc finger nuclear phosphoprotein and negative regulator of the p53 pathway, is often overexpressed in cancer cells and has been implicated in cancer cell proliferation and survival." @default.
- NCIT_C99131 NCIT_A32 NCIT_C1909 @default.
- NCIT_C99131 NCIT_A7 NCIT_C17515 @default.
- NCIT_C99131 NCIT_NHC0 "C99131" @default.
- NCIT_C99131 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C99131 NCIT_P107 "Idasanutlin" @default.
- NCIT_C99131 NCIT_P108 "Idasanutlin" @default.
- NCIT_C99131 NCIT_P207 "C3851180" @default.
- NCIT_C99131 NCIT_P210 "1229705-06-9" @default.
- NCIT_C99131 NCIT_P319 "QSQ883V35U" @default.
- NCIT_C99131 NCIT_P322 "CTRP" @default.
- NCIT_C99131 NCIT_P322 "FDA" @default.
- NCIT_C99131 NCIT_P322 "GDC" @default.
- NCIT_C99131 NCIT_P329 "715916" @default.
- NCIT_C99131 NCIT_P330 "715916" @default.
- NCIT_C99131 NCIT_P375 "Idasanutlin" @default.
- NCIT_C99131 NCIT_P399 "715916" @default.
- NCIT_C99131 normalizedInformationContent "100" @default.
- NCIT_C99131 referenceCount "1" @default.
- NCIT_C99131 hasExactSynonym "IDASANUTLIN" @default.
- NCIT_C99131 hasExactSynonym "Idasanutlin" @default.
- NCIT_C99131 hasExactSynonym "RG-7388" @default.
- NCIT_C99131 hasExactSynonym "RG7388" @default.
- NCIT_C99131 hasExactSynonym "RO-5503781" @default.
- NCIT_C99131 hasExactSynonym "RO5503781" @default.
- NCIT_C99131 inSubset NCIT_C116977 @default.
- NCIT_C99131 inSubset NCIT_C116978 @default.
- NCIT_C99131 inSubset NCIT_C128784 @default.
- NCIT_C99131 inSubset NCIT_C157711 @default.
- NCIT_C99131 inSubset NCIT_C157712 @default.
- NCIT_C99131 inSubset NCIT_C176424 @default.
- NCIT_C99131 inSubset NCIT_C177537 @default.
- NCIT_C99131 inSubset NCIT_C63923 @default.
- NCIT_C99131 type Class @default.
- NCIT_C99131 isDefinedBy ncit.owl @default.
- NCIT_C99131 label "Idasanutlin" @default.
- NCIT_C99131 subClassOf NCIT_C129839 @default.
- NCIT_C99131 subClassOf NCIT_C162996 @default.
- NCIT_C99131 subClassOf NCIT_C1908 @default.
- NCIT_C99131 subClassOf NCIT_C1909 @default.
- NCIT_C99131 subClassOf NCIT_C274 @default.
- NCIT_C99131 subClassOf NCIT_C99131 @default.