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- NCIT_C99134 IAO_0000115 "An orally active p38 mitogen-activated protein kinase (MAPK) inhibitor with potential immunomodulating, anti-inflammatory, and antineoplastic activity. Upon administration, LY3007113 inhibits the activity of p38, thereby preventing p38 MAPK-mediated signaling. This may result in the inhibition of the production of proinflammatory cytokines and the induction of tumor cell apoptosis. p38 MAPK, a serine/threonine protein kinase often upregulated in cancer cells, plays a crucial part in the production of a variety of cytokines involved in inflammation and cellular proliferation such as tumor necrosis factor (TNF) and interleukin (IL)-1 and -6." @default.
- NCIT_C99134 NCIT_A32 NCIT_C1909 @default.
- NCIT_C99134 NCIT_NHC0 "C99134" @default.
- NCIT_C99134 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C99134 NCIT_P107 "p38 MAPK Inhibitor LY3007113" @default.
- NCIT_C99134 NCIT_P108 "p38 MAPK Inhibitor LY3007113" @default.
- NCIT_C99134 NCIT_P208 "CL432952" @default.
- NCIT_C99134 NCIT_P322 "CTRP" @default.
- NCIT_C99134 NCIT_P322 "GDC" @default.
- NCIT_C99134 NCIT_P329 "716106" @default.
- NCIT_C99134 NCIT_P330 "716106" @default.
- NCIT_C99134 NCIT_P375 "p38 MAPK Inhibitor LY3007113" @default.
- NCIT_C99134 NCIT_P399 "716106" @default.
- NCIT_C99134 normalizedInformationContent "100" @default.
- NCIT_C99134 referenceCount "1" @default.
- NCIT_C99134 hasExactSynonym "LY3007113" @default.
- NCIT_C99134 hasExactSynonym "p38 MAPK Inhibitor LY3007113" @default.
- NCIT_C99134 inSubset NCIT_C116977 @default.
- NCIT_C99134 inSubset NCIT_C116978 @default.
- NCIT_C99134 inSubset NCIT_C128784 @default.
- NCIT_C99134 inSubset NCIT_C157711 @default.
- NCIT_C99134 inSubset NCIT_C157712 @default.
- NCIT_C99134 inSubset NCIT_C176424 @default.
- NCIT_C99134 inSubset NCIT_C177537 @default.
- NCIT_C99134 type Class @default.
- NCIT_C99134 isDefinedBy ncit.owl @default.
- NCIT_C99134 label "p38 MAPK Inhibitor LY3007113" @default.
- NCIT_C99134 subClassOf NCIT_C1404 @default.
- NCIT_C99134 subClassOf NCIT_C163758 @default.
- NCIT_C99134 subClassOf NCIT_C1908 @default.
- NCIT_C99134 subClassOf NCIT_C1909 @default.
- NCIT_C99134 subClassOf NCIT_C2149 @default.
- NCIT_C99134 subClassOf NCIT_C274 @default.
- NCIT_C99134 subClassOf NCIT_C471 @default.
- NCIT_C99134 subClassOf NCIT_C61074 @default.
- NCIT_C99134 subClassOf NCIT_C99134 @default.