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- NCIT_C99161 IAO_0000115 "A tropomyosin receptor kinase (TRK) inhibitor with potential antineoplastic activity. Upon administration, utatrectinib binds to TRK, thereby preventing the neurotrophin-TRK interaction and subsequent TRK activation. This may eventually result in an inhibition of tumor cell proliferation in TRK-expressing tumor cells. TRK, a receptor tyrosine kinase activated by neurotrophins, is mutated in a variety of cancer cell types and plays an important role in tumor cell growth, invasion and survival." @default.
- NCIT_C99161 NCIT_A32 NCIT_C1909 @default.
- NCIT_C99161 NCIT_A7 NCIT_C28558 @default.
- NCIT_C99161 NCIT_A7 NCIT_C33983 @default.
- NCIT_C99161 NCIT_A7 NCIT_C33984 @default.
- NCIT_C99161 NCIT_NHC0 "C99161" @default.
- NCIT_C99161 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C99161 NCIT_P107 "Utatrectinib" @default.
- NCIT_C99161 NCIT_P108 "Utatrectinib" @default.
- NCIT_C99161 NCIT_P207 "C3274575" @default.
- NCIT_C99161 NCIT_P210 "1079274-94-4" @default.
- NCIT_C99161 NCIT_P319 "VNM956Y27V" @default.
- NCIT_C99161 NCIT_P322 "CTRP" @default.
- NCIT_C99161 NCIT_P322 "FDA" @default.
- NCIT_C99161 NCIT_P322 "GDC" @default.
- NCIT_C99161 NCIT_P329 "717230" @default.
- NCIT_C99161 NCIT_P330 "717230" @default.
- NCIT_C99161 NCIT_P375 "Tropomyosin Receptor Kinase Inhibitor AZD7451" @default.
- NCIT_C99161 NCIT_P399 "717230" @default.
- NCIT_C99161 normalizedInformationContent "100" @default.
- NCIT_C99161 referenceCount "1" @default.
- NCIT_C99161 hasExactSynonym "AZD7451" @default.
- NCIT_C99161 hasExactSynonym "TRK Inhibitor AZD7451" @default.
- NCIT_C99161 hasExactSynonym "Tropomyosin Receptor Kinase Inhibitor AZD7451" @default.
- NCIT_C99161 hasExactSynonym "UTATRECTINIB" @default.
- NCIT_C99161 hasExactSynonym "Utatrectinib" @default.
- NCIT_C99161 inSubset NCIT_C116977 @default.
- NCIT_C99161 inSubset NCIT_C116978 @default.
- NCIT_C99161 inSubset NCIT_C128784 @default.
- NCIT_C99161 inSubset NCIT_C157711 @default.
- NCIT_C99161 inSubset NCIT_C157712 @default.
- NCIT_C99161 inSubset NCIT_C176424 @default.
- NCIT_C99161 inSubset NCIT_C177537 @default.
- NCIT_C99161 inSubset NCIT_C63923 @default.
- NCIT_C99161 type Class @default.
- NCIT_C99161 isDefinedBy ncit.owl @default.
- NCIT_C99161 label "Utatrectinib" @default.
- NCIT_C99161 subClassOf NCIT_C129824 @default.
- NCIT_C99161 subClassOf NCIT_C129825 @default.
- NCIT_C99161 subClassOf NCIT_C1404 @default.
- NCIT_C99161 subClassOf NCIT_C155765 @default.
- NCIT_C99161 subClassOf NCIT_C163758 @default.
- NCIT_C99161 subClassOf NCIT_C1908 @default.
- NCIT_C99161 subClassOf NCIT_C1909 @default.
- NCIT_C99161 subClassOf NCIT_C1967 @default.
- NCIT_C99161 subClassOf NCIT_C2189 @default.
- NCIT_C99161 subClassOf NCIT_C274 @default.
- NCIT_C99161 subClassOf NCIT_C471 @default.
- NCIT_C99161 subClassOf NCIT_C99161 @default.