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- NCIT_C99166 IAO_0000115 "A polypeptide derived from the Salmonella filament protein flagellin with potential radioprotective and anticancer activities. As a toll-like receptor 5 (TLR5) agonist, entolimod binds to and activates TLR5 thereby stimulating tumor necrosis factor production and activating nuclear factor kappa B (NF-kB). This induces NF-kB-mediated signaling pathways and inhibits the induction of apoptosis. This may prevent apoptosis in normal, healthy cells during radiotherapy of cancerous cells and may allow for increased doses of ionizing radiation. In addition, entolimod may inhibit radiation-independent proliferation in TLR5-expressing tumor cells." @default.
- NCIT_C99166 NCIT_A32 NCIT_C1909 @default.
- NCIT_C99166 NCIT_A7 NCIT_C30106 @default.
- NCIT_C99166 NCIT_NHC0 "C99166" @default.
- NCIT_C99166 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C99166 NCIT_P107 "Entolimod" @default.
- NCIT_C99166 NCIT_P108 "Entolimod" @default.
- NCIT_C99166 NCIT_P207 "C2353146" @default.
- NCIT_C99166 NCIT_P210 "951628-22-1" @default.
- NCIT_C99166 NCIT_P319 "R1UQ6D1ECM" @default.
- NCIT_C99166 NCIT_P322 "CTRP" @default.
- NCIT_C99166 NCIT_P322 "FDA" @default.
- NCIT_C99166 NCIT_P322 "GDC" @default.
- NCIT_C99166 NCIT_P329 "717513" @default.
- NCIT_C99166 NCIT_P330 "717513" @default.
- NCIT_C99166 NCIT_P375 "Entolimod" @default.
- NCIT_C99166 NCIT_P399 "717513" @default.
- NCIT_C99166 normalizedInformationContent "100" @default.
- NCIT_C99166 referenceCount "1" @default.
- NCIT_C99166 hasExactSynonym "CBLB502" @default.
- NCIT_C99166 hasExactSynonym "ENTOLIMOD" @default.
- NCIT_C99166 hasExactSynonym "Entolimod" @default.
- NCIT_C99166 hasExactSynonym "TLR5 Agonist CBLB502" @default.
- NCIT_C99166 inSubset NCIT_C116977 @default.
- NCIT_C99166 inSubset NCIT_C116978 @default.
- NCIT_C99166 inSubset NCIT_C128784 @default.
- NCIT_C99166 inSubset NCIT_C157711 @default.
- NCIT_C99166 inSubset NCIT_C157712 @default.
- NCIT_C99166 inSubset NCIT_C176424 @default.
- NCIT_C99166 inSubset NCIT_C177537 @default.
- NCIT_C99166 inSubset NCIT_C63923 @default.
- NCIT_C99166 type Class @default.
- NCIT_C99166 isDefinedBy ncit.owl @default.
- NCIT_C99166 label "Entolimod" @default.
- NCIT_C99166 subClassOf NCIT_C177174 @default.
- NCIT_C99166 subClassOf NCIT_C1908 @default.
- NCIT_C99166 subClassOf NCIT_C1909 @default.
- NCIT_C99166 subClassOf NCIT_C2139 @default.
- NCIT_C99166 subClassOf NCIT_C26170 @default.
- NCIT_C99166 subClassOf NCIT_C308 @default.
- NCIT_C99166 subClassOf NCIT_C797 @default.
- NCIT_C99166 subClassOf NCIT_C99166 @default.