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- NCIT_C99167 IAO_0000115 "A radioimmunoconjugate composed of basiliximab, a chimeric, mouse-human monoclonal antibody directed against the alpha subunit of interleukin-2 receptor (IL-2R alpha, CD25 or Tac antigen), and labeled with yttrium y 90, with potential antineoplastic activity. The basiliximab moiety of yttrium Y 90 basiliximab selectively binds to IL-2R alpha expressed on the surface of activated T-lymphocytes, thereby preventing IL-2 binding and blocking the IL-2-mediated activation of lymphocytes. The yttrium y 90 moiety selectively delivers a cytotoxic dose of beta radiation to lymphocytes that express the IL-2 receptor. This may prevent T cell-mediated activation of the immune system against a certain transplant and may prevent transplant rejection." @default.
- NCIT_C99167 NCIT_A32 NCIT_C1909 @default.
- NCIT_C99167 NCIT_A7 NCIT_C17073 @default.
- NCIT_C99167 NCIT_NHC0 "C99167" @default.
- NCIT_C99167 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C99167 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C99167 NCIT_P107 "Yttrium Y 90 Basiliximab" @default.
- NCIT_C99167 NCIT_P108 "Yttrium Y 90 Basiliximab" @default.
- NCIT_C99167 NCIT_P208 "CL433016" @default.
- NCIT_C99167 NCIT_P322 "CTRP" @default.
- NCIT_C99167 NCIT_P322 "GDC" @default.
- NCIT_C99167 NCIT_P329 "717514" @default.
- NCIT_C99167 NCIT_P330 "717514" @default.
- NCIT_C99167 NCIT_P375 "Yttrium Y 90 Basiliximab" @default.
- NCIT_C99167 NCIT_P399 "717514" @default.
- NCIT_C99167 normalizedInformationContent "100" @default.
- NCIT_C99167 referenceCount "1" @default.
- NCIT_C99167 hasExactSynonym "90Y Basiliximab" @default.
- NCIT_C99167 hasExactSynonym "Yttrium Y 90 Basiliximab" @default.
- NCIT_C99167 hasExactSynonym "Yttrium Y 90-DOTA-Basiliximab" @default.
- NCIT_C99167 inSubset NCIT_C116977 @default.
- NCIT_C99167 inSubset NCIT_C116978 @default.
- NCIT_C99167 inSubset NCIT_C128784 @default.
- NCIT_C99167 inSubset NCIT_C157711 @default.
- NCIT_C99167 inSubset NCIT_C157712 @default.
- NCIT_C99167 inSubset NCIT_C176424 @default.
- NCIT_C99167 inSubset NCIT_C177537 @default.
- NCIT_C99167 type Class @default.
- NCIT_C99167 isDefinedBy ncit.owl @default.
- NCIT_C99167 label "Yttrium Y 90 Basiliximab" @default.
- NCIT_C99167 subClassOf NCIT_C129819 @default.
- NCIT_C99167 subClassOf NCIT_C1446 @default.
- NCIT_C99167 subClassOf NCIT_C1511 @default.
- NCIT_C99167 subClassOf NCIT_C1512 @default.
- NCIT_C99167 subClassOf NCIT_C1908 @default.
- NCIT_C99167 subClassOf NCIT_C1909 @default.
- NCIT_C99167 subClassOf NCIT_C2124 @default.
- NCIT_C99167 subClassOf NCIT_C274 @default.
- NCIT_C99167 subClassOf NCIT_C307 @default.
- NCIT_C99167 subClassOf NCIT_C308 @default.
- NCIT_C99167 subClassOf NCIT_C99167 @default.