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- NCIT_C99172 IAO_0000115 "An orally bioavailable inhibitor of the serine/threonine protein kinase AKT (protein kinase B) with potential antineoplastic activity. Miransertib binds to and inhibits the activity of AKT in a non-ATP competitive manner, which may result in the inhibition of the PI3K/AKT signaling pathway. This may lead to the reduction in tumor cell proliferation and the induction of tumor cell apoptosis. The AKT signaling pathway is often deregulated in cancer and is associated with tumor cell proliferation, survival and migration." @default.
- NCIT_C99172 NCIT_A32 NCIT_C1909 @default.
- NCIT_C99172 NCIT_A7 NCIT_C41625 @default.
- NCIT_C99172 NCIT_NHC0 "C99172" @default.
- NCIT_C99172 NCIT_P106 "Organic Chemical" @default.
- NCIT_C99172 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C99172 NCIT_P108 "Miransertib" @default.
- NCIT_C99172 NCIT_P207 "C3274586" @default.
- NCIT_C99172 NCIT_P210 "1313881-70-7" @default.
- NCIT_C99172 NCIT_P319 "T1DQI1B52Y" @default.
- NCIT_C99172 NCIT_P322 "FDA" @default.
- NCIT_C99172 NCIT_P322 "GDC" @default.
- NCIT_C99172 NCIT_P329 "717768" @default.
- NCIT_C99172 NCIT_P330 "717768" @default.
- NCIT_C99172 NCIT_P375 "AKT Inhibitor ARQ 092" @default.
- NCIT_C99172 NCIT_P375 "Miransertib" @default.
- NCIT_C99172 NCIT_P399 "717768" @default.
- NCIT_C99172 normalizedInformationContent "100" @default.
- NCIT_C99172 referenceCount "1" @default.
- NCIT_C99172 hasExactSynonym "2-Pyridinamine, 3-(3-(4-(1-Aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo(4,5-b)pyridin-2-yl)-" @default.
- NCIT_C99172 hasExactSynonym "ARQ 092" @default.
- NCIT_C99172 hasExactSynonym "MIRANSERTIB" @default.
- NCIT_C99172 hasExactSynonym "Miransertib" @default.
- NCIT_C99172 hasExactSynonym "WHO 10490" @default.
- NCIT_C99172 inSubset NCIT_C128784 @default.
- NCIT_C99172 inSubset NCIT_C157711 @default.
- NCIT_C99172 inSubset NCIT_C157712 @default.
- NCIT_C99172 inSubset NCIT_C176424 @default.
- NCIT_C99172 inSubset NCIT_C177537 @default.
- NCIT_C99172 inSubset NCIT_C63923 @default.
- NCIT_C99172 type Class @default.
- NCIT_C99172 isDefinedBy ncit.owl @default.
- NCIT_C99172 label "Miransertib" @default.
- NCIT_C99172 subClassOf NCIT_C129824 @default.
- NCIT_C99172 subClassOf NCIT_C129825 @default.
- NCIT_C99172 subClassOf NCIT_C1404 @default.
- NCIT_C99172 subClassOf NCIT_C155764 @default.
- NCIT_C99172 subClassOf NCIT_C1742 @default.
- NCIT_C99172 subClassOf NCIT_C1908 @default.
- NCIT_C99172 subClassOf NCIT_C1909 @default.
- NCIT_C99172 subClassOf NCIT_C2189 @default.
- NCIT_C99172 subClassOf NCIT_C274 @default.
- NCIT_C99172 subClassOf NCIT_C471 @default.
- NCIT_C99172 subClassOf NCIT_C61074 @default.
- NCIT_C99172 subClassOf NCIT_C99172 @default.