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- NCIT_C99222 IAO_0000115 "An immunoconjugate consisting of a human monoclonal antibody directed against the deletion-mutant of epidermal growth factor receptor, EGFRvIII, conjugated via a non-cleavable linker to the cytotoxic agent maytansinoid DM1, with potential antineoplastic activity. The monoclonal antibody moiety of this immunoconjugate binds to EGFRvIII on tumor cell surfaces. After internalization, the DM1 moiety binds to tubulin, thereby disrupting microtubule assembly/disassembly dynamics and inhibiting cell division and the proliferation of cancer cells that express the EGFRvIII mutant. EGFRvIII, a deletion mutation of exons 2-7 in the epidermal growth factor receptor gene, is overexpressed by a variety of cancers, including glioblastoma multiforme, non-small lung carcinoma, and breast carcinoma." @default.
- NCIT_C99222 NCIT_A32 NCIT_C1909 @default.
- NCIT_C99222 NCIT_A7 NCIT_C101140 @default.
- NCIT_C99222 NCIT_NHC0 "C99222" @default.
- NCIT_C99222 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C99222 NCIT_P107 "Anti-EGFRvIII Antibody Drug Conjugate AMG 595" @default.
- NCIT_C99222 NCIT_P108 "Anti-EGFRvIII Antibody Drug Conjugate AMG 595" @default.
- NCIT_C99222 NCIT_P207 "C3274618" @default.
- NCIT_C99222 NCIT_P322 "CTRP" @default.
- NCIT_C99222 NCIT_P322 "GDC" @default.
- NCIT_C99222 NCIT_P329 "718917" @default.
- NCIT_C99222 NCIT_P330 "718917" @default.
- NCIT_C99222 NCIT_P375 "Anti-EGFRvIII Antibody Drug Conjugate AMG 595" @default.
- NCIT_C99222 NCIT_P399 "718917" @default.
- NCIT_C99222 normalizedInformationContent "100" @default.
- NCIT_C99222 referenceCount "1" @default.
- NCIT_C99222 hasExactSynonym "AMG 595" @default.
- NCIT_C99222 hasExactSynonym "Anti-EGFRvIII Antibody Drug Conjugate AMG 595" @default.
- NCIT_C99222 hasExactSynonym "Anti-EGFRvIII-DM1 Immunoconjugate AMG 595" @default.
- NCIT_C99222 inSubset NCIT_C116977 @default.
- NCIT_C99222 inSubset NCIT_C116978 @default.
- NCIT_C99222 inSubset NCIT_C128784 @default.
- NCIT_C99222 inSubset NCIT_C157711 @default.
- NCIT_C99222 inSubset NCIT_C157712 @default.
- NCIT_C99222 inSubset NCIT_C176424 @default.
- NCIT_C99222 inSubset NCIT_C177537 @default.
- NCIT_C99222 type Class @default.
- NCIT_C99222 isDefinedBy ncit.owl @default.
- NCIT_C99222 label "Anti-EGFRvIII Antibody Drug Conjugate AMG 595" @default.
- NCIT_C99222 subClassOf NCIT_C129821 @default.
- NCIT_C99222 subClassOf NCIT_C129823 @default.
- NCIT_C99222 subClassOf NCIT_C1512 @default.
- NCIT_C99222 subClassOf NCIT_C163758 @default.
- NCIT_C99222 subClassOf NCIT_C163952 @default.
- NCIT_C99222 subClassOf NCIT_C1908 @default.
- NCIT_C99222 subClassOf NCIT_C1909 @default.
- NCIT_C99222 subClassOf NCIT_C201551 @default.
- NCIT_C99222 subClassOf NCIT_C274 @default.
- NCIT_C99222 subClassOf NCIT_C307 @default.
- NCIT_C99222 subClassOf NCIT_C308 @default.
- NCIT_C99222 subClassOf NCIT_C99222 @default.