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- NCIT_C99225 IAO_0000115 "An orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities. Upon administration, duvelisib prevents the activation of the PI3K delta/gamma-mediated signaling pathways which may lead to a reduction in cellular proliferation in PI3K delta/gamma-expressing tumor cells. Unlike other isoforms of PI3K, the delta and gamma isoforms are overexpressed primarily in hematologic malignancies and inflammatory and autoimmune diseases. By selectively targeting these PI3K isoforms, PI3K signaling in normal, non-neoplastic cells is minimally or not affected which would result in a more favorable side effect profile." @default.
- NCIT_C99225 NCIT_A32 NCIT_C1909 @default.
- NCIT_C99225 NCIT_A7 NCIT_C113631 @default.
- NCIT_C99225 NCIT_A7 NCIT_C30171 @default.
- NCIT_C99225 NCIT_NHC0 "C99225" @default.
- NCIT_C99225 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C99225 NCIT_P107 "Duvelisib" @default.
- NCIT_C99225 NCIT_P108 "Duvelisib" @default.
- NCIT_C99225 NCIT_P207 "C3274621" @default.
- NCIT_C99225 NCIT_P210 "1201438-56-3" @default.
- NCIT_C99225 NCIT_P302 "relapsed or refractory chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL) and follicular lymphoma (FL)" @default.
- NCIT_C99225 NCIT_P319 "610V23S0JI" @default.
- NCIT_C99225 NCIT_P322 "CTRP" @default.
- NCIT_C99225 NCIT_P322 "FDA" @default.
- NCIT_C99225 NCIT_P322 "GDC" @default.
- NCIT_C99225 NCIT_P329 "718963" @default.
- NCIT_C99225 NCIT_P330 "718963" @default.
- NCIT_C99225 NCIT_P375 "Duvelisib" @default.
- NCIT_C99225 NCIT_P399 "718963" @default.
- NCIT_C99225 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C99225 referenceCount "2" @default.
- NCIT_C99225 hasExactSynonym "1(2H)-Isoquinolinone, 8-Chloro-2-phenyl-3-((1S)-1-(9H-purin-6-ylamino)ethyl)-" @default.
- NCIT_C99225 hasExactSynonym "8-Chloro-2-phenyl-3-((1S)-1-(7H-purin-6-ylamino)ethyl)isoquinolin-1(2H)-one" @default.
- NCIT_C99225 hasExactSynonym "Copiktra" @default.
- NCIT_C99225 hasExactSynonym "DUVELISIB" @default.
- NCIT_C99225 hasExactSynonym "Duvelisib" @default.
- NCIT_C99225 hasExactSynonym "INK-1197" @default.
- NCIT_C99225 hasExactSynonym "IPI-145" @default.
- NCIT_C99225 inSubset NCIT_C116977 @default.
- NCIT_C99225 inSubset NCIT_C116978 @default.
- NCIT_C99225 inSubset NCIT_C128784 @default.
- NCIT_C99225 inSubset NCIT_C157711 @default.
- NCIT_C99225 inSubset NCIT_C157712 @default.
- NCIT_C99225 inSubset NCIT_C173381 @default.
- NCIT_C99225 inSubset NCIT_C173383 @default.
- NCIT_C99225 inSubset NCIT_C176424 @default.
- NCIT_C99225 inSubset NCIT_C177537 @default.
- NCIT_C99225 inSubset NCIT_C63923 @default.
- NCIT_C99225 type Class @default.
- NCIT_C99225 isDefinedBy ncit.owl @default.
- NCIT_C99225 label "Duvelisib" @default.
- NCIT_C99225 subClassOf NCIT_C129824 @default.
- NCIT_C99225 subClassOf NCIT_C129825 @default.
- NCIT_C99225 subClassOf NCIT_C1404 @default.
- NCIT_C99225 subClassOf NCIT_C163758 @default.
- NCIT_C99225 subClassOf NCIT_C1742 @default.
- NCIT_C99225 subClassOf NCIT_C1908 @default.
- NCIT_C99225 subClassOf NCIT_C1909 @default.
- NCIT_C99225 subClassOf NCIT_C2152 @default.
- NCIT_C99225 subClassOf NCIT_C2189 @default.
- NCIT_C99225 subClassOf NCIT_C274 @default.
- NCIT_C99225 subClassOf NCIT_C471 @default.
- NCIT_C99225 subClassOf NCIT_C99225 @default.