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- NCIT_C99380 IAO_0000115 "An orally available, small molecule inhibitor of PIM kinases with potential antineoplastic activity. Pan-PIM kinase inhibitor AZD1208 inhibits the activities of PIM1, PIM2 and PIM3 serine/threonine kinases, which may result in the interruption of the G1/S phase cell cycle transition, thereby causing cell cycle arrest and inducing apoptosis in cells that overexpress PIMs. The growth inhibition of several leukemia cell lines by this agent is correlated with the expression levels of PIM1, which is the substrate of STAT transcription factors. PIM kinases are downstream effectors of many cytokine and growth factor signaling pathways and are upregulated in various malignancies." @default.
- NCIT_C99380 NCIT_A32 NCIT_C1909 @default.
- NCIT_C99380 NCIT_A7 NCIT_C104800 @default.
- NCIT_C99380 NCIT_A7 NCIT_C178145 @default.
- NCIT_C99380 NCIT_A7 NCIT_C18600 @default.
- NCIT_C99380 NCIT_NHC0 "C99380" @default.
- NCIT_C99380 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C99380 NCIT_P107 "pan-PIM Kinase Inhibitor AZD1208" @default.
- NCIT_C99380 NCIT_P108 "pan-PIM Kinase Inhibitor AZD1208" @default.
- NCIT_C99380 NCIT_P207 "C3274705" @default.
- NCIT_C99380 NCIT_P322 "CTRP" @default.
- NCIT_C99380 NCIT_P322 "GDC" @default.
- NCIT_C99380 NCIT_P329 "720042" @default.
- NCIT_C99380 NCIT_P330 "720042" @default.
- NCIT_C99380 NCIT_P375 "pan-PIM Kinase Inhibitor AZD1208" @default.
- NCIT_C99380 NCIT_P399 "720042" @default.
- NCIT_C99380 normalizedInformationContent "100" @default.
- NCIT_C99380 referenceCount "1" @default.
- NCIT_C99380 hasExactSynonym "AZD1208" @default.
- NCIT_C99380 hasExactSynonym "pan-PIM Kinase Inhibitor AZD1208" @default.
- NCIT_C99380 inSubset NCIT_C116977 @default.
- NCIT_C99380 inSubset NCIT_C116978 @default.
- NCIT_C99380 inSubset NCIT_C128784 @default.
- NCIT_C99380 inSubset NCIT_C157711 @default.
- NCIT_C99380 inSubset NCIT_C157712 @default.
- NCIT_C99380 inSubset NCIT_C176424 @default.
- NCIT_C99380 inSubset NCIT_C177537 @default.
- NCIT_C99380 type Class @default.
- NCIT_C99380 isDefinedBy ncit.owl @default.
- NCIT_C99380 label "pan-PIM Kinase Inhibitor AZD1208" @default.
- NCIT_C99380 subClassOf NCIT_C129824 @default.
- NCIT_C99380 subClassOf NCIT_C129825 @default.
- NCIT_C99380 subClassOf NCIT_C1404 @default.
- NCIT_C99380 subClassOf NCIT_C1908 @default.
- NCIT_C99380 subClassOf NCIT_C1909 @default.
- NCIT_C99380 subClassOf NCIT_C2189 @default.
- NCIT_C99380 subClassOf NCIT_C274 @default.
- NCIT_C99380 subClassOf NCIT_C471 @default.
- NCIT_C99380 subClassOf NCIT_C61074 @default.
- NCIT_C99380 subClassOf NCIT_C99380 @default.