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- NCIT_C99381 IAO_0000115 "A synthetic, terpene-based cannabinoid derivative devoid of cannabinoid receptors 1 and 2 agonist activity and with potential neuroprotective, antiinflammatory and antineoplastic activities. Functioning as an N-Methyl-D-aspartate (NMDA) receptor antagonist, dexanabinol protects neuronal cells against NMDA and glutamate neurotoxicity. This agent also scavenges peroxy radicals and protects neurons from the damages of reactive oxygen species. Furthermore, dexanabinol inhibits the activity of nuclear factor kappa B (NF-kB), thereby preventing the expression of NF-kB target genes, such as tumor necrosis factor alpha, cytokines and inducible nitric oxide synthase. As a result, this agent may restore apoptotic processes in cancerous cells. NF-kB is activated in a variety of cancer cells and plays a key role in the regulation of apoptosis and cellular proliferation." @default.
- NCIT_C99381 NCIT_A32 NCIT_C1909 @default.
- NCIT_C99381 NCIT_A7 NCIT_C102460 @default.
- NCIT_C99381 NCIT_A7 NCIT_C98149 @default.
- NCIT_C99381 NCIT_NHC0 "C99381" @default.
- NCIT_C99381 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C99381 NCIT_P107 "Dexanabinol" @default.
- NCIT_C99381 NCIT_P108 "Dexanabinol" @default.
- NCIT_C99381 NCIT_P207 "C0526471" @default.
- NCIT_C99381 NCIT_P210 "112924-45-5" @default.
- NCIT_C99381 NCIT_P319 "R6VT8U5372" @default.
- NCIT_C99381 NCIT_P322 "CTRP" @default.
- NCIT_C99381 NCIT_P322 "FDA" @default.
- NCIT_C99381 NCIT_P322 "GDC" @default.
- NCIT_C99381 NCIT_P329 "720043" @default.
- NCIT_C99381 NCIT_P330 "720043" @default.
- NCIT_C99381 NCIT_P350 "C25H38O3" @default.
- NCIT_C99381 NCIT_P375 "Dexanabinol" @default.
- NCIT_C99381 NCIT_P399 "720043" @default.
- NCIT_C99381 normalizedInformationContent "100" @default.
- NCIT_C99381 referenceCount "1" @default.
- NCIT_C99381 hasExactSynonym "1,1-Dimethylheptyl-11-hydroxytetrahydrocannabinol" @default.
- NCIT_C99381 hasExactSynonym "7-Hydroxy-delta-6-tetrahydrocannabinoldimethylheptyl" @default.
- NCIT_C99381 hasExactSynonym "DEXANABINOL" @default.
- NCIT_C99381 hasExactSynonym "Dexanabinol" @default.
- NCIT_C99381 hasExactSynonym "HU-211" @default.
- NCIT_C99381 inSubset NCIT_C116977 @default.
- NCIT_C99381 inSubset NCIT_C116978 @default.
- NCIT_C99381 inSubset NCIT_C128784 @default.
- NCIT_C99381 inSubset NCIT_C157711 @default.
- NCIT_C99381 inSubset NCIT_C157712 @default.
- NCIT_C99381 inSubset NCIT_C176424 @default.
- NCIT_C99381 inSubset NCIT_C177537 @default.
- NCIT_C99381 inSubset NCIT_C63923 @default.
- NCIT_C99381 type Class @default.
- NCIT_C99381 isDefinedBy ncit.owl @default.
- NCIT_C99381 label "Dexanabinol" @default.
- NCIT_C99381 subClassOf NCIT_C129839 @default.
- NCIT_C99381 subClassOf NCIT_C1509 @default.
- NCIT_C99381 subClassOf NCIT_C1908 @default.
- NCIT_C99381 subClassOf NCIT_C1909 @default.
- NCIT_C99381 subClassOf NCIT_C26170 @default.
- NCIT_C99381 subClassOf NCIT_C274 @default.
- NCIT_C99381 subClassOf NCIT_C99381 @default.