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- NCIT_C99765 IAO_0000115 "A fully human monoclonal antibody directed against the human vascular endothelial growth factor C (VEGFC or Flt4 ligand) with potential antiangiogenic activity. Anti-VEGFC monoclonal antibody VGX-100 specifically binds to and inhibits VEGFC protein, thereby preventing its binding to VEGFR3 (FLT4) or VEGFR2 (KDR or FLK1). This may prevent VEGFC-mediated signaling and may lead to the inhibition of vascular and lymphatic endothelial cell proliferation. The inhibition of tumor angiogenesis and lymphangiogenesis may eventually decrease tumor cell proliferation and prevent metastasis. VEGFC is overexpressed in a variety of cancer cells, and is associated with increased invasiveness and decreased survival." @default.
- NCIT_C99765 NCIT_A32 NCIT_C1909 @default.
- NCIT_C99765 NCIT_A7 NCIT_C21441 @default.
- NCIT_C99765 NCIT_NHC0 "C99765" @default.
- NCIT_C99765 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C99765 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C99765 NCIT_P107 "Anti-VEGFC Monoclonal Antibody VGX-100" @default.
- NCIT_C99765 NCIT_P108 "Anti-VEGFC Monoclonal Antibody VGX-100" @default.
- NCIT_C99765 NCIT_P208 "CL433490" @default.
- NCIT_C99765 NCIT_P319 "RJ12A315RN" @default.
- NCIT_C99765 NCIT_P322 "CTRP" @default.
- NCIT_C99765 NCIT_P322 "FDA" @default.
- NCIT_C99765 NCIT_P322 "GDC" @default.
- NCIT_C99765 NCIT_P329 "724066" @default.
- NCIT_C99765 NCIT_P330 "724066" @default.
- NCIT_C99765 NCIT_P375 "Anti-VEGFC Monoclonal Antibody VGX-100" @default.
- NCIT_C99765 NCIT_P399 "724066" @default.
- NCIT_C99765 NCIT_R124 NCIT_C17710 @default.
- NCIT_C99765 NCIT_R124 NCIT_C17828 @default.
- NCIT_C99765 NCIT_R124 NCIT_C18219 @default.
- NCIT_C99765 NCIT_R124 NCIT_C19986 @default.
- NCIT_C99765 NCIT_R124 NCIT_C40474 @default.
- NCIT_C99765 normalizedInformationContent "100" @default.
- NCIT_C99765 referenceCount "1" @default.
- NCIT_C99765 hasExactSynonym "Anti-VEGFC Monoclonal Antibody VGX-100" @default.
- NCIT_C99765 hasExactSynonym "VEGF-C mAb VGX-100" @default.
- NCIT_C99765 hasExactSynonym "VGX-100" @default.
- NCIT_C99765 inSubset NCIT_C116977 @default.
- NCIT_C99765 inSubset NCIT_C116978 @default.
- NCIT_C99765 inSubset NCIT_C128784 @default.
- NCIT_C99765 inSubset NCIT_C157711 @default.
- NCIT_C99765 inSubset NCIT_C157712 @default.
- NCIT_C99765 inSubset NCIT_C176424 @default.
- NCIT_C99765 inSubset NCIT_C177537 @default.
- NCIT_C99765 inSubset NCIT_C63923 @default.
- NCIT_C99765 type Class @default.
- NCIT_C99765 isDefinedBy ncit.owl @default.
- NCIT_C99765 label "Anti-VEGFC Monoclonal Antibody VGX-100" @default.
- NCIT_C99765 subClassOf NCIT_C129821 @default.
- NCIT_C99765 subClassOf NCIT_C129822 @default.
- NCIT_C99765 subClassOf NCIT_C163758 @default.
- NCIT_C99765 subClassOf NCIT_C1742 @default.
- NCIT_C99765 subClassOf NCIT_C1908 @default.
- NCIT_C99765 subClassOf NCIT_C1909 @default.
- NCIT_C99765 subClassOf NCIT_C198860 @default.
- NCIT_C99765 subClassOf NCIT_C20401 @default.
- NCIT_C99765 subClassOf NCIT_C2496 @default.
- NCIT_C99765 subClassOf NCIT_C274 @default.
- NCIT_C99765 subClassOf NCIT_C307 @default.
- NCIT_C99765 subClassOf NCIT_C308 @default.
- NCIT_C99765 subClassOf NCIT_C99765 @default.