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- NCIT_C99899 IAO_0000115 "An oligoclonal therapeutic composed of three fully human monoclonal antibodies targeting epidermal growth factor receptor (EGFR or ErbB1), with potential antineoplastic activity. Upon administration of MM-151, the three antibodies bind to distinct, non-overlapping epitopes of EGFR, thereby preventing the binding of a full range of both high and low affinity EGFR ligands and inhibiting EGFR-ERK-mediated signaling. This eventually inhibits tumor cell proliferation in EGFR-overexpressing tumor cells. Furthermore, multi antibody-antigen bindings cause crosslinking of EGFR and downregulate receptor signalings that are mediated via heterodimerization of EGFR with other members of the EGFR family. EGFR, a receptor tyrosine kinase overexpressed in a variety of cancer cell types, is a key regulator of cancer cell proliferation, apoptosis, invasion, and metastasis." @default.
- NCIT_C99899 NCIT_A32 NCIT_C1909 @default.
- NCIT_C99899 NCIT_A7 NCIT_C17068 @default.
- NCIT_C99899 NCIT_NHC0 "C99899" @default.
- NCIT_C99899 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C99899 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C99899 NCIT_P107 "Anti-EGFR Monoclonal Antibody Mixture MM-151" @default.
- NCIT_C99899 NCIT_P108 "Anti-EGFR Monoclonal Antibody Mixture MM-151" @default.
- NCIT_C99899 NCIT_P207 "C3275035" @default.
- NCIT_C99899 NCIT_P322 "CTRP" @default.
- NCIT_C99899 NCIT_P322 "GDC" @default.
- NCIT_C99899 NCIT_P329 "724591" @default.
- NCIT_C99899 NCIT_P330 "724591" @default.
- NCIT_C99899 NCIT_P375 "Anti-EGFR Monoclonal Antibody Mixture MM-151" @default.
- NCIT_C99899 NCIT_P399 "724591" @default.
- NCIT_C99899 NCIT_R124 NCIT_C17710 @default.
- NCIT_C99899 NCIT_R124 NCIT_C17828 @default.
- NCIT_C99899 NCIT_R124 NCIT_C18219 @default.
- NCIT_C99899 NCIT_R124 NCIT_C19986 @default.
- NCIT_C99899 NCIT_R124 NCIT_C40474 @default.
- NCIT_C99899 normalizedInformationContent "100" @default.
- NCIT_C99899 referenceCount "1" @default.
- NCIT_C99899 hasExactSynonym "Anti-EGFR Monoclonal Antibody Mixture MM-151" @default.
- NCIT_C99899 hasExactSynonym "MM-151" @default.
- NCIT_C99899 inSubset NCIT_C116977 @default.
- NCIT_C99899 inSubset NCIT_C116978 @default.
- NCIT_C99899 inSubset NCIT_C128784 @default.
- NCIT_C99899 inSubset NCIT_C157711 @default.
- NCIT_C99899 inSubset NCIT_C157712 @default.
- NCIT_C99899 inSubset NCIT_C176424 @default.
- NCIT_C99899 inSubset NCIT_C177537 @default.
- NCIT_C99899 type Class @default.
- NCIT_C99899 isDefinedBy ncit.owl @default.
- NCIT_C99899 label "Anti-EGFR Monoclonal Antibody Mixture MM-151" @default.
- NCIT_C99899 subClassOf NCIT_C129821 @default.
- NCIT_C99899 subClassOf NCIT_C129822 @default.
- NCIT_C99899 subClassOf NCIT_C133878 @default.
- NCIT_C99899 subClassOf NCIT_C163758 @default.
- NCIT_C99899 subClassOf NCIT_C163952 @default.
- NCIT_C99899 subClassOf NCIT_C1908 @default.
- NCIT_C99899 subClassOf NCIT_C1909 @default.
- NCIT_C99899 subClassOf NCIT_C20401 @default.
- NCIT_C99899 subClassOf NCIT_C274 @default.
- NCIT_C99899 subClassOf NCIT_C307 @default.
- NCIT_C99899 subClassOf NCIT_C308 @default.
- NCIT_C99899 subClassOf NCIT_C99899 @default.