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- NCIT_C99900 IAO_0000115 "A radioimmunoconjugate containing rituximab, a recombinant chimeric murine/human antibody directed against the human CD20 antigen, conjugated with the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA) and labeled with the radioisotope copper Cu 64 with potential diagnostic properties upon positron emission tomography (PET) imaging. The monoclonal antibody moiety of copper Cu 64-DOTA-Rituximab specifically binds to cell surface antigen CD20. Upon binding, the radioisotope moiety may be detected using PET, thereby allowing the imaging and quantification of CD20-expressing tumor cells. CD20 is a non-glycosylated phosphoprotein that is exclusively expressed on B cells during most stages of B cell development and is often overexpressed in B-cell malignancies." @default.
- NCIT_C99900 NCIT_A7 NCIT_C38896 @default.
- NCIT_C99900 NCIT_NHC0 "C99900" @default.
- NCIT_C99900 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C99900 NCIT_P106 "Indicator, Reagent, or Diagnostic Aid" @default.
- NCIT_C99900 NCIT_P107 "Copper Cu 64-DOTA-Rituximab" @default.
- NCIT_C99900 NCIT_P108 "Copper Cu 64-DOTA-Rituximab" @default.
- NCIT_C99900 NCIT_P207 "C3275036" @default.
- NCIT_C99900 NCIT_P322 "CTRP" @default.
- NCIT_C99900 NCIT_P329 "724695" @default.
- NCIT_C99900 NCIT_P330 "724695" @default.
- NCIT_C99900 NCIT_P399 "724695" @default.
- NCIT_C99900 normalizedInformationContent "100" @default.
- NCIT_C99900 referenceCount "1" @default.
- NCIT_C99900 hasExactSynonym "64Cu-DOTA-Rituximab" @default.
- NCIT_C99900 hasExactSynonym "Copper Cu 64-DOTA-Rituximab" @default.
- NCIT_C99900 inSubset NCIT_C116977 @default.
- NCIT_C99900 inSubset NCIT_C116978 @default.
- NCIT_C99900 inSubset NCIT_C176424 @default.
- NCIT_C99900 type Class @default.
- NCIT_C99900 isDefinedBy ncit.owl @default.
- NCIT_C99900 label "Copper Cu 64-DOTA-Rituximab" @default.
- NCIT_C99900 subClassOf NCIT_C1446 @default.
- NCIT_C99900 subClassOf NCIT_C1511 @default.
- NCIT_C99900 subClassOf NCIT_C1512 @default.
- NCIT_C99900 subClassOf NCIT_C1908 @default.
- NCIT_C99900 subClassOf NCIT_C1909 @default.
- NCIT_C99900 subClassOf NCIT_C2124 @default.
- NCIT_C99900 subClassOf NCIT_C307 @default.
- NCIT_C99900 subClassOf NCIT_C308 @default.
- NCIT_C99900 subClassOf NCIT_C99900 @default.