FRINK Linked Data Fragments server

Matches in Ubergraph for { <http://purl.obolibrary.org/obo/OBI_0500003> ?p ?o ?g. }

• OBI_0500003 BFO_0000051 BFO_0000001 @default.
• OBI_0500003 BFO_0000051 BFO_0000002 @default.
• OBI_0500003 BFO_0000051 BFO_0000031 @default.
• OBI_0500003 BFO_0000051 COB_0000061 @default.
• OBI_0500003 BFO_0000051 COB_0000069 @default.
• OBI_0500003 BFO_0000051 COB_0000076 @default.
• OBI_0500003 BFO_0000051 COB_0000079 @default.
• OBI_0500003 BFO_0000051 IAO_0000005 @default.
• OBI_0500003 BFO_0000051 IAO_0000007 @default.
• OBI_0500003 BFO_0000051 IAO_0000030 @default.
• OBI_0500003 BFO_0000051 IAO_0000033 @default.
• OBI_0500003 BFO_0000051 IAO_0000104 @default.
• OBI_0500003 BFO_0000051 OBI_0000272 @default.
• OBI_0500003 BFO_0000051 OBI_0000750 @default.
• OBI_0500003 COB_0000047 BFO_0000001 @default.
• OBI_0500003 COB_0000047 BFO_0000002 @default.
• OBI_0500003 COB_0000047 BFO_0000031 @default.
• OBI_0500003 COB_0000047 COB_0000061 @default.
• OBI_0500003 COB_0000047 COB_0000069 @default.
• OBI_0500003 COB_0000047 COB_0000076 @default.
• OBI_0500003 COB_0000047 COB_0000077 @default.
• OBI_0500003 COB_0000047 COB_0000079 @default.
• OBI_0500003 COB_0000047 IAO_0000005 @default.
• OBI_0500003 COB_0000047 IAO_0000007 @default.
• OBI_0500003 COB_0000047 IAO_0000030 @default.
• OBI_0500003 COB_0000047 IAO_0000033 @default.
• OBI_0500003 COB_0000047 IAO_0000104 @default.
• OBI_0500003 COB_0000047 OBI_0000272 @default.
• OBI_0500003 COB_0000047 OBI_0000750 @default.
• OBI_0500003 IAO_0000111 "cross over design" @default.
• OBI_0500003 IAO_0000112 "PMID: 17601993-Objective: HIV-infected patients with lipodystrophy (HIV-lipodystrophy) are insulin resistant and have elevated plasma free fatty acid (FFA) concentrations. We aimed to explore the mechanisms underlying FFA-induced insulin resistance in patients with HIV-lipodystrophy. Research Design and Methods: Using a randomized placebo-controlled cross-over design, we studied the effects of an overnight acipimox-induced suppression of FFA on glucose and FFA metabolism by using stable isotope labelled tracer techniques during basal conditions and a two-stage euglycemic, hyperinsulinemic clamp (20 mU insulin/m(2)/min; 50 mU insulin/m(2)/min) in nine patients with nondiabetic HIV-lipodystrophy. All patients received antiretroviral therapy. Biopsies from the vastus lateralis muscle were obtained during each stage of the clamp. Results: Acipimox treatment reduced basal FFA rate of appearance by 68.9% (52.6%-79.5%) and decreased plasma FFA concentration by 51.6 % (42.0%-58.9%), (both, P < 0.0001). Endogenous glucose production was not influenced by acipimox. During the clamp the increase in glucose-uptake was significantly greater after acipimox treatment compared to placebo (acipimox: 26.85 (18.09-39.86) vs placebo: 20.30 (13.67-30.13) mumol/kg/min; P < 0.01). Insulin increased phosphorylation of Akt (Thr(308)) and GSK-3beta (Ser(9)), decreased phosphorylation of glycogen synthase (GS) site 3a+b and increased GS-activity (I-form) in skeletal muscle (P < 0.01). Acipimox decreased phosphorylation of GS (site 3a+b) (P < 0.02) and increased GS-activity (P < 0.01) in muscle. Conclusion: The present study provides direct evidence that suppression of lipolysis in patients with HIV-lipodystrophy improves insulin-stimulated peripheral glucose-uptake. The increased glucose-uptake may in part be explained by increased dephosphorylation of GS (site 3a+b) resulting in increased GS activity." @default.
• OBI_0500003 IAO_0000114 IAO_0000120 @default.
• OBI_0500003 IAO_0000115 "a repeated measure design which ensures that experimental units receive, in sequence, the treatment (or the control), and then, after a specified time interval (aka *wash-out periods*), switch to the control (or treatment). In this design, subjects (patients in human context) serve as their own controls, and randomization may be used to determine the ordering which a subject receives the treatment and control" @default.
• OBI_0500003 IAO_0000117 "Philippe Rocca-Serra" @default.
• OBI_0500003 IAO_0000119 "(source: http://www.sbu.se/Filer/Content0/publikationer/1/literaturesearching_1993/glossary.html)" @default.
• OBI_0500003 IAO_0000136 BFO_0000001 @default.
• OBI_0500003 IAO_0000136 BFO_0000002 @default.
• OBI_0500003 IAO_0000136 BFO_0000017 @default.
• OBI_0500003 IAO_0000136 BFO_0000020 @default.
• OBI_0500003 IAO_0000136 COB_0000033 @default.
• OBI_0500003 IAO_0000136 COB_0000502 @default.
• OBI_0500003 IAO_0000136 PATO_0000001 @default.
• OBI_0500003 RO_0002131 BFO_0000001 @default.
• OBI_0500003 RO_0002131 BFO_0000002 @default.
• OBI_0500003 RO_0002131 BFO_0000031 @default.
• OBI_0500003 RO_0002131 COB_0000061 @default.
• OBI_0500003 RO_0002131 COB_0000069 @default.
• OBI_0500003 RO_0002131 COB_0000076 @default.
• OBI_0500003 RO_0002131 COB_0000079 @default.
• OBI_0500003 RO_0002131 IAO_0000005 @default.
• OBI_0500003 RO_0002131 IAO_0000007 @default.
• OBI_0500003 RO_0002131 IAO_0000030 @default.
• OBI_0500003 RO_0002131 IAO_0000033 @default.
• OBI_0500003 RO_0002131 IAO_0000104 @default.
• OBI_0500003 RO_0002131 OBI_0000272 @default.
• OBI_0500003 RO_0002131 OBI_0000750 @default.
• OBI_0500003 RO_0002131 OBI_0500000 @default.
• OBI_0500003 RO_0002323 BFO_0000001 @default.
• OBI_0500003 RO_0002323 BFO_0000002 @default.
• OBI_0500003 RO_0002323 BFO_0000031 @default.
• OBI_0500003 RO_0002323 COB_0000061 @default.
• OBI_0500003 RO_0002323 COB_0000069 @default.
• OBI_0500003 RO_0002323 COB_0000076 @default.
• OBI_0500003 RO_0002323 COB_0000079 @default.
• OBI_0500003 RO_0002323 IAO_0000005 @default.
• OBI_0500003 RO_0002323 IAO_0000007 @default.
• OBI_0500003 RO_0002323 IAO_0000030 @default.
• OBI_0500003 RO_0002323 IAO_0000033 @default.
• OBI_0500003 RO_0002323 IAO_0000104 @default.
• OBI_0500003 RO_0002323 OBI_0000272 @default.
• OBI_0500003 RO_0002323 OBI_0000750 @default.
• OBI_0500003 RO_0002323 OBI_0500000 @default.
• OBI_0500003 normalizedInformationContent "95.413332725061409" @default.
• OBI_0500003 referenceCount "2" @default.
• OBI_0500003 type Class @default.
• OBI_0500003 isDefinedBy obi.owl @default.
• OBI_0500003 label "cross over design" @default.
• OBI_0500003 subClassOf BFO_0000001 @default.
• OBI_0500003 subClassOf BFO_0000002 @default.
• OBI_0500003 subClassOf BFO_0000031 @default.
• OBI_0500003 subClassOf COB_0000061 @default.
• OBI_0500003 subClassOf COB_0000069 @default.
• OBI_0500003 subClassOf COB_0000079 @default.
• OBI_0500003 subClassOf IAO_0000030 @default.
• OBI_0500003 subClassOf IAO_0000033 @default.
• OBI_0500003 subClassOf IAO_0000104 @default.
• OBI_0500003 subClassOf OBI_0000115 @default.
• OBI_0500003 subClassOf OBI_0500000 @default.
• OBI_0500003 subClassOf OBI_0500002 @default.
• OBI_0500003 subClassOf OBI_0500003 @default.
• OBI_0500003 category Entity @default.
• OBI_0500003 category InformationContentEntity @default.
• OBI_0500003 category NamedThing @default.