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- B000acfa24ba2a7cbde1b005a34727c47 NCIT_P378 "NCI" @default.
- B000acfa24ba2a7cbde1b005a34727c47 type Axiom @default.
- B000acfa24ba2a7cbde1b005a34727c47 annotatedProperty IAO_0000115 @default.
- B000acfa24ba2a7cbde1b005a34727c47 annotatedSource NCIT_C71692 @default.
- B000acfa24ba2a7cbde1b005a34727c47 annotatedTarget "A controlled-release, intratumoral paclitaxel formulation in which paclitaxel is incorporated into a thermosensitive, biodegradable triblock copolymer consisting of poly(lactide-co-glycolide) (PLGA) and polyethylene glycol (PEG). Upon intratumoral injection, paclitaxel is released slowly and continuously into tumor tissues from the gelled thermosensitive triblock copolymer over a period of 4 to 6 weeks; in tumor cells, paclitaxel binds to tubulin and inhibits the disassembly-assembly dynamics of microtubules, resulting in cell cycle arrest and cell death. The thermosensitive triblock copolymer component of this formulation transforms from a water-soluble polymer at room temperature to a water-insoluble, biodegradable gel depot at body temperature; intratumoral controlled-release of paclitaxel from the gel minimizes systemic exposure to paclitaxel and the paclitaxel toxicity profile." @default.