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- B0087e887caacaac4639744e355a798c2 NCIT_P378 "NCI" @default.
- B0087e887caacaac4639744e355a798c2 type Axiom @default.
- B0087e887caacaac4639744e355a798c2 annotatedProperty IAO_0000115 @default.
- B0087e887caacaac4639744e355a798c2 annotatedSource NCIT_C3868 @default.
- B0087e887caacaac4639744e355a798c2 annotatedTarget "A stromal tumor most commonly seen in the gastrointestinal tract. Rare cases of solitary masses in the omentum or the mesentery have also been reported (extragastrointestinal gastrointestinal stromal tumor). It is a tumor that differentiates along the lines of interstitial cells of Cajal. Most cases contain KIT- or PDGFRA-activating mutations. Until recently, surgery has been the only effective therapy for this tumor. However, many patients still experience recurrence. Conventional chemotherapy and radiation therapy have been of limited value. A KIT tyrosine kinase inhibitor, imatinib mesylate (also known as STI-571 or Gleevec), is now effective in the treatment of relapsed and unresectable cases." @default.