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- B008b44837e7d8b219a2b23f0f5445d59 NCIT_P378 "NCI" @default.
- B008b44837e7d8b219a2b23f0f5445d59 type Axiom @default.
- B008b44837e7d8b219a2b23f0f5445d59 annotatedProperty IAO_0000115 @default.
- B008b44837e7d8b219a2b23f0f5445d59 annotatedSource NCIT_C47575 @default.
- B008b44837e7d8b219a2b23f0f5445d59 annotatedTarget "The mononitrate salt form of isosorbide, an organic nitrate with vasodilator activity. Isosorbide mononitrate relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle, resulting in dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition, isosorbide mononitrate relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area. (NCI05)" @default.