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- B00ac525792cedd29d27ed3fa5e9b707b NCIT_P378 "NCI" @default.
- B00ac525792cedd29d27ed3fa5e9b707b type Axiom @default.
- B00ac525792cedd29d27ed3fa5e9b707b annotatedProperty IAO_0000115 @default.
- B00ac525792cedd29d27ed3fa5e9b707b annotatedSource NCIT_C739 @default.
- B00ac525792cedd29d27ed3fa5e9b707b annotatedTarget "A long-acting barbituric acid derivative with antipsychotic property. Phenobarbital binds to and activates the gamma-aminobutyric acid (GABA)-A receptor, thereby mimicking the inhibitory actions of GABA in the brain. The activation effects of the phenobarbital-receptor-ionophore complex include increased frequency of chloride channel openings, membrane hyperpolarization and ultimately synaptic inhibition and decreased neuronal excitability. In addition, this agent inhibits glutamate induced depolarization." @default.