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- B011fe172ca9d8830e02ce0a8e93988c8 NCIT_P378 "NCI" @default.
- B011fe172ca9d8830e02ce0a8e93988c8 type Axiom @default.
- B011fe172ca9d8830e02ce0a8e93988c8 annotatedProperty IAO_0000115 @default.
- B011fe172ca9d8830e02ce0a8e93988c8 annotatedSource NCIT_C61315 @default.
- B011fe172ca9d8830e02ce0a8e93988c8 annotatedTarget "A isoindolinone derivative and potent inhibitor of the nuclear enzyme poly (ADP-ribose) polymerase (PARP) with chemosensitization and radiosensitization properties. INO-1001 inhibits PARP, which may result in inhibition of tumor cell DNA repair mechanisms and, so, tumor cell resistance to chemotherapy and radiation therapy. PARP enzymes are activated by DNA breaks and have been implicated in the repair of DNA single-strand breaks (SSB)." @default.