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- B016c6b28b6192df6b51b0a57966f86da NCIT_P378 "NCI" @default.
- B016c6b28b6192df6b51b0a57966f86da type Axiom @default.
- B016c6b28b6192df6b51b0a57966f86da annotatedProperty IAO_0000115 @default.
- B016c6b28b6192df6b51b0a57966f86da annotatedSource NCIT_C200545 @default.
- B016c6b28b6192df6b51b0a57966f86da annotatedTarget "A human immunoglobulin G4 (IgG4) agonistic monoclonal antibody directed against the inducible T‐cell costimulatory receptor CD137 (4-1BB; tumor necrosis factor receptor superfamily member 9; TNFRSF9), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD137 monoclonal antibody PE0116 is selectively activated in the tumor microenvironment (TME), and targets, binds to, crosslinks and activates CD137 expressed on a variety of leukocyte subsets including activated T-lymphocytes and natural killer (NK) cells. This enhances CD137-mediated signaling, induces T-cell proliferation, cytokine production and promotes T-cell mediated anti-tumor immune responses. CD137, a surface glycoprotein of the tumor necrosis factor receptor superfamily, is an inducible costimulatory receptor that plays a key role in T-cell proliferation, survival and cytolytic activity to promote anti-tumor immunity." @default.