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- B0179727d49fff33d0ce0020d4354ba7d NCIT_P378 "NCI" @default.
- B0179727d49fff33d0ce0020d4354ba7d type Axiom @default.
- B0179727d49fff33d0ce0020d4354ba7d annotatedProperty IAO_0000115 @default.
- B0179727d49fff33d0ce0020d4354ba7d annotatedSource NCIT_C95223 @default.
- B0179727d49fff33d0ce0020d4354ba7d annotatedTarget "The hydrochloride salt of nilotinib, an orally bioavailable aminopyrimidine-derivative Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity. Designed to overcome imatinib resistance, nilotinib binds to and stabilizes the inactive conformation of the kinase domain of the Abl protein of the Bcr-Abl fusion protein, resulting in the inhibition of the Bcr-Abl-mediated proliferation of Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) cells. This agent also inhibits the receptor tyrosine kinases platelet-derived growth factor receptor (PDGF-R) and c-kit, a receptor tyrosine kinase mutated and constitutively activated in most gastrointestinal stromal tumors (GISTs). With a binding mode that is energetically more favorable than that of imatinib, nilotinib has been shown to have an approximately 20-fold increased potency in kinase and proliferation assays compared to imatinib." @default.