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- B019887fa2c9dd75fae7a41306de0a04f NCIT_P378 "NCI" @default.
- B019887fa2c9dd75fae7a41306de0a04f type Axiom @default.
- B019887fa2c9dd75fae7a41306de0a04f annotatedProperty IAO_0000115 @default.
- B019887fa2c9dd75fae7a41306de0a04f annotatedSource NCIT_C61721 @default.
- B019887fa2c9dd75fae7a41306de0a04f annotatedTarget "An amphetamine derivative and a sympathomimetic stimulant with anti-obesity and appetite-suppressant properties. Diethylpropion stimulates neurons to release and maintain high levels of catecholamines including dopamine and norepinephrine resulting in a suppression of hunger signals and appetite. This agent may also indirectly affect leptin-neuropeptide Y (NPY) neurotransmission, which exerts control on metabolic processes such as food intake and body weight homeostasis. Via elevated catecholamine, diethylpropion indirectly elevates leptin levels in the brain, which in turn inhibits production of NPY, a potent stimulator of feeding behavior, thereby preventing the initiation of eating, increasing energy expenditure, and decreasing fat storage." @default.